USE OF INACTIVATED NONREPLICATING MODIFIED VACCINIA VIRUS ANKARA (MVA) AS MONOIMMUNOTHERAPY OR IN COMBINATION WITH IMMUME CHECKPOINT BLOCKING AGENTS FOR SOLID TUMORS
First Claim
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1. A method for treating a solid malignant tumor in a subject in need thereof, the method comprising delivering to cells of the tumor a therapeutically effective amount of inactivated modified vaccinia Ankara virus (inactivated-MVA), thereby resulting in the treatment of the tumor.
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Abstract
The present disclosure relates to infection-competent, but nonreplicative inactivated modified vaccinia Ankara (MVA) and its use as immunotherapy, alone, or in combination with immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to inducing an immune response in a subject diagnosed with a solid malignant tumor.
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Citations
63 Claims
- 1. A method for treating a solid malignant tumor in a subject in need thereof, the method comprising delivering to cells of the tumor a therapeutically effective amount of inactivated modified vaccinia Ankara virus (inactivated-MVA), thereby resulting in the treatment of the tumor.
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- 38. A method for treating a solid malignant tumor in a subject in need thereof, the method comprising delivering to tumor cells of the subject a therapeutically effective amount of inactivated modified vaccinia Ankara virus (inactivated-MVA) and conjointly administering to the subject a therapeutically effective amount of an immune checkpoint blocking agent.
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Specification