THERMORESPONSIVE BIOCONJUGATES AND THEIR CONTROLLED DELIVERY OF CARGO
First Claim
1. A method for delivering a bioconjugate to a target matrix, comprising(a) introducing a bioconjugate self-assembled into particles to a target matrix, wherein the bioconjugate comprises a first molecule comprising an elastin-like peptide (ELP), a second molecule capable of self-associating into an oligomer, and a linker connecting the first molecule with the second molecule, and(b) increasing the temperature of the target matrix to disassemble the particles at the target matrix.
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Accused Products
Abstract
The present invention provides a bioconjugate. The bioconjugate comprises a first molecule comprising an elast-in-like peptide (ELP), a second molecule capable of self-associating into an oligomer, and a linker connecting the first molecule with the second molecule. The bioconjugate is self-assembled into particles, which are disassembled when the temperature is increased. Also provided is a method for delivering a bioconjugate to a target matrix, comprising (a) introducing a bioconjugate self-assembled into particles to a target matrix, wherein the bioconjugate comprises a first molecule comprising an elastin-like peptide (ELP), a second molecule capable of self-associating into an oligomer, and a linker connecting the first molecule with the second molecule, and (b) increasing the temperature of the target matrix to disassemble the particles at the target matrix.
0 Citations
49 Claims
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1. A method for delivering a bioconjugate to a target matrix, comprising
(a) introducing a bioconjugate self-assembled into particles to a target matrix, wherein the bioconjugate comprises a first molecule comprising an elastin-like peptide (ELP), a second molecule capable of self-associating into an oligomer, and a linker connecting the first molecule with the second molecule, and (b) increasing the temperature of the target matrix to disassemble the particles at the target matrix.
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2. (canceled)
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3. (canceled)
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14. (canceled)
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15. (canceled)
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17-38. -38. (canceled)
- 39. A bioconjugate comprising a first molecule comprising an elastin-like peptide (ELP), a second molecule capable of self-associating into an oligomer, and a linker connecting the first molecule with the second molecule, wherein the bioconjugate is self-assembled into particles, wherein the particles are disassembled when the temperature is increased.
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40. (canceled)
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41. (canceled)
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49-70. -70. (canceled)
Specification