NEGATIVE PRESSURE WOUND THERAPY DRESSINGS COMPRISING (METH)ACRYLATE PRESSURE-SENSITIVE ADHESIVE WITH ENHANCED ADHESION TO WET SURFACES

• US 20180243463A1
• Filed: 08/19/2016
• Published: 08/30/2018
• Est. Priority Date: 08/31/2015
• Status: Active Grant

• Current Assignee: Solventum Intellectual Properties Company (Solventum Corp.)
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Chatterjee, Joon, Fung, Simon S.
• Granted Patent: US 11,660,371 B2
• Time in Patent Office: Days
• CPC Class Codes: A61F 13/0253 characterized by the adhesive material
• CPC Class Codes: A61F 13/0263 especially adapted for island dressings
• CPC Class Codes: A61F 13/05 specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61M 1/915 Constructional details of the pressure distribution manifold
• CPC Class Codes: C08L 33/10 Homopolymers or copolymers of methacrylic acid esters
• CPC Class Codes: C09J 133/12 Homopolymers or copolymers of methyl methacrylate
• CPC Class Codes: C09J 4/00 Adhesives based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; adhesives, based on monomers of macromolecular compounds of groups C09J183/00 - C09J183/16

Abstract

Negative pressure wound dressings comprising pressure-sensitive adhesives with enhanced adhesion to wet surfaces, obtained from crosslinking a pre-adhesive composition comprising poly(meth)acrylate macromolecules that comprise a number-average molecular weight of from about 25000 to about 200000, and methods of using such dressings.

Claims

1. A negative pressure wound therapy dressing comprising:

a backing bearing on at least a portion of a major surface thereof a wet-stick pressure-sensitive adhesive, and comprising at least one opening that is configured so that a vacuum can be applied therethrough,

wherein the wet-stick pressure-sensitive adhesive is the crosslinking reaction product of a pre-adhesive composition comprising poly(meth)acrylate macromolecules that comprise a number-average molecular weight of from about 25000 to about 200000,

and wherein the pre-adhesive composition exhibits a T_g of less than about minus 20°

C. and exhibits a storage modulus of from about 4 Pa to about 10000 Pa at 25°

C.

2. The negative pressure wound therapy dressing of claim 1 wherein the wet-stick pressure-sensitive adhesive is provided as an annular strip that extends around a perimeter of the backing and that is configured to be adhered to skin surrounding a wound so that the dressing provides a sealed wound bed that is sealed by the wet-stick pressure-sensitive adhesive.

3. The negative pressure wound therapy dressing of claim 2 wherein the opening in the backing is configured to accept a vacuum tubing through which a partial vacuum can be applied to the sealed wound bed.

4. The negative pressure wound therapy dressing of claim 2 wherein no sealing component is used to seal the wound bed, other than the wet-stick pressure-sensitive adhesive.

5. The negative pressure wound therapy dressing of claim 1 wherein the dressing comprises at least one body that comprises a wound-packing material.

6. A negative pressure wound therapy system comprising the negative pressure wound therapy dressing of claim 1 and a vacuum source, wherein the negative pressure wound therapy dressing is configured to be fluidly connected to the vacuum source.

7. The negative pressure wound therapy system of claim 6, wherein the negative pressure wound therapy dressing is fluidly connected to the vacuum source by a vacuum line that includes a liquid-collection canister between the negative pressure wound therapy dressing and the vacuum source.

8. The negative pressure wound therapy dressing of claim 1 wherein the poly(meth)acrylate macromolecules of the pre-adhesive composition comprise a number-average molecular weight of from about 25000 to about 100000.

9. The negative pressure wound therapy dressing of claim 1 wherein the pre-adhesive composition exhibits a storage modulus of from about 100 Pa to about 1000 Pa.

10. The negative pressure wound therapy dressing of claim 1 wherein the pre-adhesive composition exhibits a viscosity from about 10 Pa·

s to about 800 Pa·

s at 25°

C.

11. The negative pressure wound therapy dressing of claim 1 wherein the poly(meth)acrylate macromolecules make up at least about 95 wt. % of the macromolecular components of the pre-adhesive composition.

12. The negative pressure wound therapy dressing of claim 1 wherein the poly(meth)acrylate macromolecules consist essentially of nonpolar (meth)acrylate monomer units with a T_g of less than 0°

C.

13. The negative pressure wound therapy dressing of claim 1 wherein the poly(meth)acrylate macromolecules consist essentially of alkyl (meth)acrylate monomer units.

14. The negative pressure wound therapy dressing of claim 1 wherein the poly(meth)acrylate macromolecules of the pre-adhesive composition are substantially linear macromolecules.

15. The negative pressure wound therapy dressing of claim 1 wherein the wet-stick pressure-sensitive adhesive exhibits a Peak Pull Force of at least about 3000 g when tested according to the Wet-Stick Test Method.

16. The adhesive article of claim 1 wherein the wet-stick pressure-sensitive adhesive includes from about 2 wt. % to about 10 wt. % of a plasticizer, based on the total weight of the wet-stick pressure-sensitive adhesive.

17. The negative pressure wound therapy dressing of claim 1 wherein the poly(meth)acrylate macromolecules are the reaction product of a first, synthesis reaction of a monomer mixture that included at least one chain transfer agent and wherein at least some of the poly(meth)acrylate macromolecules include at least one chain transfer agent residue.

18. The adhesive article of claim 1 wherein the pressure-sensitive adhesive exhibits a gel content of from about 40 to about 70%.

19. The negative pressure wound therapy dressing of claim 1 wherein the pressure-sensitive adhesive is an e-beam crosslinking reaction product of the pre-adhesive composition.

20. The negative pressure wound therapy dressing of claim 1 wherein the pressure-sensitive adhesive is a photo-crosslinking reaction product of the pre-adhesive composition and wherein at least some of the poly(meth)acrylate macromolecules of the crosslinked reaction product include at least one photo-activatable crosslinker residue.

21. A method of performing negative pressure wound therapy, the method comprising;

applying the negative pressure wound therapy dressing of claim 1 to skin so that the wet-stick pressure-sensitive adhesive of the negative pressure wound therapy dressing bonds to skin surrounding the wound to provide a sealed wound bed;

and,

applying a partial vacuum through the opening in the backing of the negative pressure wound therapy dressing so as to apply a negative pressure to the sealed wound bed.

22. The method of claim 21 wherein the partial vacuum is applied so that the negative pressure in the sealed wound bed is in a range of from about −

30 mm Hg to about −

200 mg Hg.