APPARATUS FOR INHALER TESTING

• US 20180259379A1
• Filed: 01/19/2018
• Published: 09/13/2018
• Est. Priority Date: 03/13/2017
• Status: Active Grant

• Current Assignee: Copley Scientific Limited
• Original Assignee: Copley Scientific Limited
• Inventors: COPLEY, Mark Andrew, BRADLEY, Benjamin, EVANS, Ian Christopher, WRIGHT, Jonathan Charles Stephen
• Granted Patent: US 10,451,459 B2
• Time in Patent Office: Days
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 16/026 specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
• CPC Class Codes: A61M 16/14 by mixing different fluids, one of them being in a liquid phase
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/70 with testing or calibration facilities
• CPC Class Codes: G01F 1/36 the pressure or differential pressure being created by the use of flow constriction
• CPC Class Codes: G01M 1/00 Testing static or dynamic balance of machines or structures

Abstract

There is disclosed inhaler testing apparatus, in which at least one flow regulation valve, such as a needle valve, is located within a conduit. The flow regulation valve divides the conduit into inlet and outlet sides of the valve. The inlet side is arranged for connection to an inhaler and the outlet side for connection to a vacuum source. An electric motor provides variable adjustment of a flow opening through the valve. At least one sensor senses pressure or flow rate in the inlet side and a controller automatically adjusts the flow opening through the valve in response to readings from the at least one sensor. The apparatus may also comprise a shut off valve, such as a solenoid valve.

Claims

1. An inhaler testing apparatus, comprising:

a conduit having at least one flow regulation valve located within the conduit and dividing the conduit into inlet and outlet sides of the valve, the inlet side being arranged for connection to an inhaler and the outlet side for connection to a vacuum source,

an electric motor for variable adjustment of a flow opening through the valve;

at least one sensor for sensing pressure or flow rate in the inlet side; and

,

a controller for automatically adjusting the flow opening through the valve in response to readings from the at least one sensor.

2. The apparatus as claimed in claim 1, wherein the valve comprises a needle valve.

3. The apparatus as claimed in claim 1, wherein the at least one sensor comprises a pressure sensor in fluid communication with the inlet side and/or the outlet side, and the controller is configured to adjust a dimension of the flow opening through the valve in response to a pressure sensed in the inlet and/or outlet portion.

4. The apparatus as claimed in claim 1, wherein the at least one sensor comprises a differential pressure sensor arranged to sense the pressure drop across an inhaler connected to the inlet side.

5. The apparatus as claimed in claim 1, wherein the at least one sensor comprises a first absolute pressure sensor in fluid communication with the inlet side, and/or a second absolute pressure sensor in fluid communication with the outlet side.

6. The apparatus as claimed in claim 5, wherein the controller is configured to automatically control adjustment of the flow area through the valve in response to pressure sensed by the first and/or second absolute pressure sensor.

7. The apparatus as claimed in claim 1, wherein the valve comprises a rotatable valve member, and the controller is configured to control rotation of the valve member relative to a fully open and/or fully closed valve member position to achieve a desired pressure drop or flow rate through an inhaler connected to the inlet side in response to readings from the at least one sensor.

8. The apparatus as claimed in claim 1, comprising an intermediate coupling in the force path between the motor and the valve, wherein the intermediate coupling member is configured to allow for axial relative movement between the motor and the valve, in use.

9. The apparatus as claimed in claim 8, wherein the intermediate coupling comprises first and second coupling members which are opposingly engaged for torque transfer there-between and slidably coupled to one another.

10. The apparatus as claimed in claim 1, wherein the motor comprises an encoder configured to provide motor position feedback to the controller, and the controller is configured to automatically control operation of the valve in response to feedback received from the encoder.

11. The apparatus according to claim 1, wherein the controller operates according to an iterative control scheme using feedback from the at least one sensor to incrementally adjust the flow regulation valve according to a difference between a desired pressure or flow rate and a sensed pressure or flow rate for a current and/or previous iteration of the control scheme.

12. The apparatus according to claim 1, wherein the controller is a PID controller.

13. The apparatus according to claim 1, wherein the controller controls adjustment of the flow regulation valve at least in part as a function of the flow resistance through the valve.

14. The apparatus as claimed in claim 1, wherein the motor comprises a valve condition sensor for sensing any, or any combination of position, electrical current or torque applied to the valve, the valve condition sensor configured to provide feedback to the controller, and the controller is configured to cease operation of the motor in response to the feedback.

15. The apparatus as claimed in any claim 1, wherein the controller is configured to perform automatic calibration of the valve by running a routine to determine a fully open and/or fully closed configuration of the valve.

16. The apparatus as claimed in claim 15, wherein the controller is configured to automatically determine a fully open and/or closed configuration of the valve in response to pressure sensed by at least one pressure sensor.

17. The apparatus as claimed in claim 1, wherein the apparatus comprises at least one flow sensor for sensing fluid flow on the inlet side, and the controller automatically controls operation of the motor to adjust the valve flow opening through the valve in response to fluid flow sensed by the at least one flow sensor.

18. The apparatus as claimed in claim 1, further comprising a shut off valve for the conduit, wherein the shut off valve is also under the control of the controller.

19. The apparatus as claimed in claim 1, comprising a user interface for inputting a desired pressure drop across an inhaler to be connected to the inlet side and the controller being arranged to automatically adjust the flow regulation valve to achieve said input pressure drop.

20. The apparatus as claimed in claim 1, comprising a manual actuator for manual setting of the position of the flow regulation valve.

21. The apparatus as claimed in claim 20, wherein the manual actuator is connected to the motor, so as to cause rotation of the flow regulation valve via the electric motor.

22. The apparatus as claimed in claim 1, further comprising a particle collector connectable on the inlet side between the flow regulation valve and an inhaler in use.

23. The apparatus as claimed in claim 1, offering each of the following modes of adjustment of the flow regulation valve:

automatic adjustment according to pressure;

automatic adjustment according to flow rate; and

manual adjustment by a manual actuator.

24. A data carrier comprising machine readable instructions for the operation of one or more processors of an inhaler testing apparatus controller to:

i. receive a desired pressure or flow rate condition for an inlet side of a flow regulation valve of a flow conduit of the inhaler testing apparatus

ii. receive sensor readings from a pressure or flow rate sensor in the inlet side of the flow conduit whilst a vacuum is being applied to an outlet side of the flow conduit downstream of the flow regulation valve by a pump;

iii. compare the desired condition with the received sensor readings, determine an adjustment to the flow regulation valve and implement the adjustment to the flow regulation valve by outputting control instructions to an electric motor drivingly connected to said flow regulation valve;

iv. iteratively repeat said steps ii and iii in order to converge on the desired condition; and

v. control cessation of the electric motor once the desired condition is achieved.

25. The data carrier according to claim 24, wherein the controller is further arranged to control operation of a shut off valve to selectively allow fluid communication between the vacuum source and the inlet side via the flow regulation valve.