PATCH

• US 20180289631A1
• Filed: 06/14/2018
• Published: 10/11/2018
• Est. Priority Date: 07/26/2012
• Status: Active Grant

• Current Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Original Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Inventors: Sonobe, Atsushi, Yasukochi, Takashi, Takada, Yasunori
• Granted Patent: US 11,123,305 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 31/407 condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 9/7053 obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
• CPC Class Codes: A61K 9/7061 Polyacrylates
• CPC Class Codes: A61K 9/7069 obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide

Abstract

In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.

Claims

1. A patch, comprising:

a support layer; and

an adhesive agent layer formed on the support layer and comprising asenapine and/or a pharmaceutically acceptable salt thereof, dibutylhydroxytoluene, and an adhesive base agent,

wherein the adhesive base agent is at least one selected from the group consisting of a rubber-based adhesive agent and a silicone polymer, and a content of the dibutylhydroxytoluene in the adhesive agent layer is in a range of 0.1% by mass to 3.0% by mass.

2. The patch according to claim 1, wherein the adhesive agent layer further comprises a maleic acid alkali salt.

3. The patch according to claim 2, wherein a content of the maleic acid alkali salt in the adhesive agent layer has is in a range of 0.5% by mass to 15% by mass.

4. The patch according to claim 2, wherein the maleic acid alkali salt is at least one of disodium maleate and monosodium maleate.

5. The patch according to claim 1, wherein the adhesive base agent is the rubber-based adhesive agent.

6. The patch according to claim 5, wherein a content of the rubber-based adhesive agent in the adhesive agent layer is in a range of 10% by mass to 50% by mass.

7. The patch according to claim 5, wherein the rubber-based adhesive agent is at least one selected from the group consisting of a styrene-isoprene-styrene block copolymer, polyisobutylene, and a silicone rubber.

8. The patch according to claim 1, wherein the adhesive agent layer further comprises at least one absorption enhancer selected from the group consisting of isostearyl alcohol, capric acid, propylene glycol monolaurate, isopropyl myristate, isopropyl palmitate, lauric acid diethanolamide, propylene glycol, and polyethylene glycol.

9. The patch according to claim 3, wherein the maleic acid alkali salt is at least one of disodium maleate and monosodium maleate.

10. The patch according to claim 6, wherein the rubber-based adhesive agent is at least one selected from the group consisting of a styrene-isoprene-styrene block copolymer, polyisobutylene, and a silicone rubber.

11. The patch according to claim 2, wherein the adhesive base agent is the rubber-based adhesive agent.

12. The patch according to claim 11, wherein a content of the rubber-based adhesive agent in the adhesive agent layer is in a range of 10% by mass to 50% by mass.

13. The patch according to claim 11, wherein the rubber-based adhesive agent is at least one selected from the group consisting of a styrene-isoprene-styrene block copolymer, polyisobutylene, and a silicone rubber.

14. The patch according to claim 12, wherein the rubber-based adhesive agent is at least one selected from the group consisting of a styrene-isoprene-styrene block copolymer, polyisobutylene, and a silicone rubber.

15. The patch according to claim 3, wherein the adhesive base agent is the rubber-based adhesive agent.

16. The patch according to claim 15, wherein a content of the rubber-based adhesive agent in the adhesive agent layer is in a range of 10% by mass to 50% by mass.

17. The patch according to claim 15, wherein the rubber-based adhesive agent is at least one selected from the group consisting of a styrene-isoprene-styrene block copolymer, polyisobutylene, and a silicone rubber.

18. The patch according to claim 16, wherein the rubber-based adhesive agent is at least one selected from the group consisting of a styrene-isoprene-styrene block copolymer, polyisobutylene, and a silicone rubber.

19. The patch according to claim 4, wherein the adhesive base agent is the rubber-based adhesive agent.

20. The patch according to claim 19, wherein a content of the rubber-based adhesive agent in the adhesive agent layer is in a range of 10% by mass to 50% by mass.