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CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

  • US 20180305704A1
  • Filed: 12/11/2017
  • Published: 10/25/2018
  • Est. Priority Date: 12/12/2012
  • Status: Abandoned Application
First Claim
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1. A composition comprising (i) a population of eukaryotic cells, and (ii) a library comprising a plurality of 100 or more CRISPR-Cas9 system guide RNAs;

  • wherein each of the eukaryotic cells contains one or more of the guide RNAs and thus the guide RNAs of the library are integrated into the population of eukaryotic cells; and

    each guide RNA comprises an engineered guide sequence that targets a unique genomic locus in a eukaryotic cell, whereby the library targets a plurality of target sequences of genomic loci in the population of eukaryotic cells.

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