DIGITAL SEQUENCING USING MASS LABELS
First Claim
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1. A method of gene sequencing by mass spectroscopy said method comprising release and detection of mass labeled nucleic acids.
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Abstract
The invention provides a means to sequence a gene by mass spectroscopy by release and detection of mass labeled nucleic acids. Mass labels are designed as chain terminators nucleic acid and optimal for ionization by the mass spectrometric method used and there is no loss of sensitivity across genes sequenced and the amplification can be minimized.
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16 Claims
- 1. A method of gene sequencing by mass spectroscopy said method comprising release and detection of mass labeled nucleic acids.
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