METHOD FOR INHIBITING OR MASKING FISHY ODOURS

• US 20180318189A1
• Filed: 10/28/2015
• Published: 11/08/2018
• Est. Priority Date: 10/28/2015
• Status: Active Grant

• Current Assignee: Symrise AG
• Original Assignee: Symrise AG
• Inventors: Hatt, Hanns, Gisselmann, Gunter, Wallrabenstein, Ivonne, Singer, Marco, Panten, Johannes
• Granted Patent: US 10,639,251 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 8/342 Alcohols having more than seven atoms in an unbroken chain
• CPC Class Codes: A61Q 13/00 Formulations or additives for perfume preparations essential oils or perfumes per se C11B9/00
• CPC Class Codes: C11B 9/0019 carbocylic acids; Salts or esters thereof
• CPC Class Codes: G01N 2500/04 Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
• CPC Class Codes: G01N 33/5041 involving analysis of members of signalling pathways
• CPC Class Codes: G01N 33/566 using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds

Abstract

Norlimbanol in general and particularly its isomer mixture Timberol®, an amber-woody fragrance, is able to specifically inhibit the trimethylamine-induced h TAAR5 activation up to 96%. Moreover, human psychophysical data showed that the presence of Timberol® increases the olfactory detection threshold for the characteristic fishy odor of trimethylamine by almost one order of magnitude.

Claims

1. A method for inhibiting or masking fish odour comprising the following steps:

(a) providing a composition comprising at least one isomer of norlimbanol according to formula (Ia) and (Ib)

2. The method of claim 1, wherein said at least one isomer of Norlimbanol is Timberol®

.

3. The method of claim 1, wherein said at least one isomer of Norlimbanol is present in the carrier in an amount of 0.00001 to about 0.1% b.w.—

calculated on the total composition.

4. The method of claim 1, wherein said composition is applied to or brought into contact with human skin or hair.

5. The method of claim 1, wherein said composition is applied to or brought into contact with a hard surface.

6. The method of claim 1, wherein said composition is a fragrance or an air refresher.

7. The method of claim 1, wherein said composition is a cosmetic or personal care composition.

8. The method of claim 1, wherein said composition is a cleaning composition.

9-10. -10. (canceled)

11. A method for identifying compounds capable for inhibiting and/or masking fishy odours comprising the following steps:

(a) providing a source of TAAR5-transfected cells;

(b) adding an amount of TMA as the agonist to said source of TAAR5 cells;

(c) adding an amount of putative antagonist substance to said source of TAAR5 cells; and

(d) measuring the hTAAR5-mediated TMA response.