THERAPEUTIC TARGETING OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 (IRAK4) IN CANCERS CHARACTERIZED BY REARRANGEMENTS IN THE MIXED LINEAGE LEUKEMIA GENE (MLL-r)
First Claim
1. A method for treating a cancer characterized by a rearrangement in the mixed lineage leukemia gene (MLL-r) in a subject in need thereof, the method comprising administering a therapeutic amount of a therapeutic agent that inhibits the biological activity of interleukin-1 receptor-associated kinase 4 (IRAK4).
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Accused Products
Abstract
Disclosed are methods for treating cancers associated with rearrangements in the mixed lineage leukemia gene (MLL-r), including MLL-r leukemia. The methods typically include administering a therapeutic amount of one or more therapeutic agents that inhibit the biological activity of one or more members of the interleukin-1 signaling pathway such inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4).
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Citations
20 Claims
- 1. A method for treating a cancer characterized by a rearrangement in the mixed lineage leukemia gene (MLL-r) in a subject in need thereof, the method comprising administering a therapeutic amount of a therapeutic agent that inhibits the biological activity of interleukin-1 receptor-associated kinase 4 (IRAK4).
- 12. A compound having a formula III:
- 16. A compound having a formula IV:
Specification