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HOMOGENEOUS PROCESS FOR HYDRODEHALOGENATING HALOGENATED HETEROARYL COMPOUNDS

  • US 20180334433A1
  • Filed: 11/16/2016
  • Published: 11/22/2018
  • Est. Priority Date: 11/19/2015
  • Status: Active Grant
First Claim
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1. A homogeneous process for hydrodehalogenating a halo-substituted C3-C20 heteroaryl starting material to form a non-halogenated C3-C20 heteroaryl product and/or a halo-substituted C3-C20 heteroaryl product, wherein the halo-substituted C3-C20 heteroaryl product has at least one less halogen substituent than the halo-substituted C3-C20 heteroaryl starting material, the process comprising the step of:

  • hydrogenating the halo-substituted C3-C20 heteroaryl starting material in the presence of a rhodium or ruthenium complex, molecular hydrogen, a base and a solvent, wherein the process is carried out in a monophasic solvent system and the molar ratio of base to each halogen substituent to be removed is at least 1;

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