MUTLI-PROBE MICROSTRUCTURED ARRAYS

• US 20180338712A1
• Filed: 07/17/2015
• Published: 11/29/2018
• Est. Priority Date: 07/17/2014
• Status: Abandoned Application

• Current Assignee: Imperial College Innovations Ltd. (Imperial College London)
• Original Assignee: Imperial Innovations Limited (Imperial College London)
• Inventors: Cass, Tony, Sharma, Sanjiv
• Application Number:
  US15/326,828
• Publication Number:
  US 20180338712A1
• Time in Patent Office: Days
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 2562/125 characterised by the manufacture of electrodes
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/685 Microneedles

Abstract

A microstructured electrode array comprising a base (12) with a plurality of groups of probes (14) formed thereon, each group (13) of probes having a conductive layer formed thereon so that the group (13) forms a single electrode, wherein the electrodes are electrically isolated from each other.

Claims

1. A microstructured electrode array comprising a base with a plurality of groups of probes formed thereon, each group of probes having a conductive layer formed thereon so that the group forms a single electrode, wherein the electrodes are electrically isolated from each other.

2. A sensor comprising a microstructured electrode array according to claim 1, and a processor having an input connected to each of the electrodes to receive a signal therefrom, and arranged to process the signals to generate a sensor output signal.

3. A sensor according to claim 2 wherein one of the electrodes is arranged to form a reference electrode and counter electrode and at least one of the electrodes is arranged to form a sensing electrode.

4. A sensor according to claim 3 wherein the at least one sensing electrode is functionalized so as to produce a voltage/current signal indicative of the presence of an analyte, and the reference electrode is not so functionalized.

5. A sensor according to claim 2 wherein two of the sensing electrodes are functionalized in different ways to respond to the presence of different analytes.

6. A sensor according to claim 2 wherein at least two of the sensing electrodes are functionalized in the same way and the processor is arranged to generate an average of the signals from at least two electrodes.

7. A sensor according to claim 2 wherein at least three of the sensing electrodes are functionalized in the same way and the processor is arranged to identify the signal from at least two of the at least three electrodes as being most similar to each other, and to base the output signal at least predominantly on the signals from those two electrodes.

8. A sensor according to claim 5 wherein one of the sensing electrodes is functionalized to respond to the presence of at least two analytes, and one of the electrodes is a compensation electrode functionalized so as to respond to only one of the two analytes, and the processor is arranged to compare the signals so as to generate a sensing signal indicative of the presence of the other of the analytes.

9. A sensor according to claim 2 wherein the sensing electrodes are usable to diagnose the health or functioning of the sensor.

10. A sensor according to claim 9 wherein impedance measurements are used to check whether the sensor is performing optimally.

11. A sensor according to claim 2 wherein the processor is arranged to store a sequence of sample values of the signals and to analyse the sample values.

12. A sensor according to claim 2 wherein the processor is arranged to analyse the signals and detect the occurrence of a predetermined change in the signals over time.

13. A stimulation device comprising an electrode array according to claim 1, a power source, and a controller arranged to generate a stimulation signal from the power source and control the application of the stimulating signal to each of the electrodes.

14-16. -16. (canceled)