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METHOD FOR TREATING CANCER PATIENTS WITH SEVERE RENAL IMPAIRMENT

  • US 20180338976A1
  • Filed: 08/03/2018
  • Published: 11/29/2018
  • Est. Priority Date: 02/05/2016
  • Status: Active Grant
First Claim
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1. A method for treating cancer, comprising:

  • detecting a creatinine clearance of a patient before starting a treatment; and

    starting the treatment by orally administering to the patient with a creatinine clearance of less than 30 mL/min a combination drug comprising α





    -trifluorothymidine (FTD) and 5-chloro-6-[(2-iminopyrrolidine-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione hydrochloride in a molar ratio of 1;

    0.5, a dose of 30 to 40 mg/m2/day as FTD-equivalent, in two to four divided doses.

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