METHOD FOR TREATING CANCER PATIENTS WITH SEVERE RENAL IMPAIRMENT
First Claim
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1. A method for treating cancer, comprising:
- detecting a creatinine clearance of a patient before starting a treatment; and
starting the treatment by orally administering to the patient with a creatinine clearance of less than 30 mL/min a combination drug comprising α
,α
,α
-trifluorothymidine (FTD) and 5-chloro-6-[(2-iminopyrrolidine-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione hydrochloride in a molar ratio of 1;
0.5, a dose of 30 to 40 mg/m2/day as FTD-equivalent, in two to four divided doses.
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Abstract
A method for treating cancer in patients with creatinine clearance of 15 mL/min or more and less than 30 mL/min, including dividing a combination drug containing α,α,α-trifluorothymidine (FTD) and 5-chloro-6-[(2-iminopyrrolidine-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione hydrochloride in a molar ratio of 1:0.5, in a dose of 30 to 50 mg/m2/day as FTD-equivalent, into two to four times a day, and orally administering it to the patient.
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Citations
51 Claims
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1. A method for treating cancer, comprising:
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detecting a creatinine clearance of a patient before starting a treatment; and starting the treatment by orally administering to the patient with a creatinine clearance of less than 30 mL/min a combination drug comprising α
,α
,α
-trifluorothymidine (FTD) and 5-chloro-6-[(2-iminopyrrolidine-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione hydrochloride in a molar ratio of 1;
0.5, a dose of 30 to 40 mg/m2/day as FTD-equivalent, in two to four divided doses. - View Dependent Claims (2, 3, 4, 5, 6, 7, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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8-28. -28 (canceled)
Specification