PIPETTOR SYSTEM

• US 20180348248A1
• Filed: 01/30/2018
• Published: 12/06/2018
• Est. Priority Date: 03/03/2015
• Status: Active Grant

• Current Assignee: Highres Biosolutions Incorporated (BJA Croonen BV)
• Original Assignee: Highres Biosolutions Incorporated (BJA Croonen BV)
• Inventors: NICHOLS, Michael, GUARRACINA, Louis J.
• Granted Patent: US 10,444,251 B2
• Time in Patent Office: Days
• CPC Class Codes: B01L 3/0227 Details of motor drive means B01L3/0231, B01L3/0234 take precedence
• CPC Class Codes: B01L 3/0237 Details of electronic control, e.g. relating to user interface
• CPC Class Codes: G01N 2035/1076 plurality or independently movable heads
• CPC Class Codes: G01N 35/0099 comprising robots or similar manipulators robots per se B25J
• CPC Class Codes: G01N 35/10 Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices G01N35/0099 takes precedence
• CPC Class Codes: G01N 35/1011 Control of the position or alignment of the transfer device
• CPC Class Codes: G01N 35/1065 Multiple transfer devices
• CPC Class Codes: G01N 35/1072 with provision for selective pipetting of individual channels

Abstract

Various embodiments include a system having a pipetting chamber, a set of pipettor cartridges docked in the pipetting chamber, a gantry system mounted on a ceiling within the pipetting chamber, the gantry system including at least one stationary track aligned in a first direction, and a movable track aligned in a second direction distinct from the first direction, the movable track coupled to the at least one stationary track, and a carrier configured to transport each of the set of pipettor cartridges to a pipetting location within the pipetting chamber, the carrier configured to move each pipettor cartridge in a third direction perpendicular to both the first and second directions.

Claims

1. A method comprising:

docking a set of pipettor cartridges in a pipetting chamber;

providing a tray dock movably mounted within the pipetting chamber;

providing a gantry system mounted on a ceiling within the pipetting chamber, the gantry system having at least one stationary track aligned in a first direction, and a movable track aligned in a second direction distinct from the first direction, the movable track coupled to the at least one stationary track; and

transporting, with a carrier, each pipettor cartridge of the set of pipettor cartridges to a pipetting location within the pipetting chamber, where the carrier moves each pipettor cartridge in a third direction perpendicular to both the first and second directions;

moving the tray dock within the pipetting chamber relative to the pipetting location, where the tray dock has more than one tray dock sections each being separate and distinct from each other and each of the more than one tray dock sections docks with a different corresponding pipetting tray; and

swapping the different corresponding pipetting trays at the pipetting location by moving each of the more than one tray dock sections past each other relative to the pipetting location.

2. The method of claim 1, further comprising moving the dock with an arm, coupled to the tray dock, in each of the first direction, the second direction, and the third direction.

3. The method of claim 1, further comprising storing pipetting trays in a storage chamber coupled to the pipetting chamber.

4. The method of claim 3, further comprising storing pipetting trays in a storage carousel within the storage chamber.

5. The method of claim 4, further comprising moving the pipetting trays, with a robotic arm of the storage chamber, between the pipetting chamber and the storage chamber.

6. The method of claim 3, further comprising:

providing a set of fluid reservoirs coupled with an exterior of at least one of the storage chamber or the pipetting chamber; and

providing a set of fluid conduits fluidly connected with the set of fluid reservoirs and the set of pipettor cartridges through the pipetting chamber.

7. The method of claim 6, further comprising providing a pump within the pipetting chamber, the pump fluidly connected with the set of fluid conduits, wherein the pump pumps fluid from the set of fluid reservoirs to the set of pipettor cartridges.

8. The method of claim 3, wherein the storage chamber is located below the pipetting chamber.

9. The method of claim 8, further comprising:

providing a first set of doors on a side of the pipetting chamber, the first set of doors for accessing the pipetting chamber; and

providing a second set of doors on a side of the storage chamber shared with the side of the pipetting chamber, the second set of doors for accessing the stored pipetting trays.

10. The method of claim 1, wherein each pipettor cartridge of the set of pipettor cartridges is provided with a casing, a mount on a top side of the casing, a set of pipettes extending from a bottom side of the casing, and an access door on a side of the casing between the top side and the bottom side.

11. The method of claim 10, wherein each pipettor cartridge of the set of pipettor cartridges is further provided with at least one handle on the casing for gripping the casing, and a display indicating at least one of power to the pipettor cartridge or a status of a pipetting procedure.

12. The method of claim 1, further comprising rotating the carrier about an axis of the carrier to at least one of engage a pipettor cartridge, disengage a pipettor cartridge, or facilitate pipetting via a pipettor cartridge, wherein the axis of the carrier is parallel to the third direction.

13. The method of claim 1, wherein the at least one stationary track includes two distinct stationary tracks aligned in parallel, the two distinct stationary tracks aligned perpendicular to the movable track.

14. The method of claim 1, wherein the set of pipettor cartridges is docked to the ceiling of the pipetting chamber.

15. The method of claim 1, wherein the set of pipettor cartridges is docked in a docking station within the pipetting chamber.

16. The method of claim 1, wherein the more than one tray dock sections are disposed within the pipetting chamber to move freely past each other and a pipettor cartridge on the carrier at the pipetting location and swap the different corresponding pipetting trays at the pipetting location.

17. The method of claim 1, further comprising effecting replacement, with the gantry system, at the pipetting location of a pipettor cartridge of the set of pipettor cartridges with another pipettor cartridge of the set of pipettor cartridges independent of tray dock section movement swapping the different corresponding pipettor trays at the pipetting location, wherein the carrier moves freely in the first, second, and third direction between the pipetting location and different docking locations of the set of pipettor cartridges.

18. The method of claim 1, further comprising swapping the different corresponding pipetting trays at an opening location of a tray passage opening between a storage chamber and the pipetting chamber, the opening location being away from the pipetting location, wherein each tray dock section moves past each other tray dock section relative to the opening location and the storage chamber is coupled to the pipetting chamber.

19. The method of claim 1, wherein at least a corresponding pipetting tray docked to one of the more than one tray dock sections is of a different type than another corresponding pipetting tray docked to another of the more than one tray dock sections.

20. The method of claim 1, wherein the more than one tray dock sections include a number of tray dock sections so that swapping movement of tray dock sections is effected at the pipetting location with a tray dock section located at the opening location.

21-42. -42. (canceled)