METHOD FOR ADJUSTING HARDNESS OF STICK-SHAPED BASE MATERIAL COMPRISING LIPID PEPTIDE COMPOUND

• US 20180353414A1
• Filed: 06/14/2016
• Published: 12/13/2018
• Est. Priority Date: 06/24/2015
• Status: Active Grant

• Current Assignee: Nissan Chemical Industries Limited (Shin-Etsu Chemical Company Limited)
• Original Assignee: Nissan Chemical Industries Limited (Shin-Etsu Chemical Company Limited)
• Inventors: KASHINO, Tsubasa
• Granted Patent: US 10,639,263 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 8/0229 Sticks
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/39 Derivatives containing from 2 to 10 oxyalkylene groups
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

A method for adjusting hardness of a stick-shaped base material including a lipid peptide compound. A method for adjusting hardness of a gelled solid base material for skin external application including a surfactant, water, and lipid peptide compound including compounds of formulae (1) or similar,

wherein R¹ is a C_9-23 aliphatic group, R² is a hydrogen atom or similar, and R³ is a —(CH₂)n-X group, n is a number from 1 to 4, and X is amino group, the method including adding a pH adjuster to a solution in which the material is dissolved, or a solution including a surfactant, water, and lipid peptide compound including at least one of compounds of formulae (1) to (3) or pharmaceutically usable salts thereof, to adjust the pH of the solution to a weak acidic to neutral range, causing gelation of the solution to form a solid base material for skin external application.

Claims

1. A method for adjusting hardness of a gelled solid base material for skin external application, the solid base material including a surfactant, water, and a lipid peptide compound including at least one of compounds of formulae (1) to (3) below or pharmaceutically usable salts of the compounds, the method comprising:

adding a pH adjuster to a solution in which the solid base material for skin external application is dissolved, or a solution including a surfactant, water, and a lipid peptide compound including at least one of compounds of formulae (1) to (3) below or pharmaceutically usable salts of the compounds, to adjust the pH of the solution to a weak acidic to neutral range; and

subsequently, causing gelation of the solution to form a solid base material for skin external application

2. The method according to claim 1, wherein the solution adjusted to be in the weak acidic to neutral range has a pH of 3.0 to 7.5.

3. The method according to claim 1, wherein the pH adjuster is acetic acid, hydrochloric acid, sulfuric acid, sodium hydroxide, potassium hydroxide, or aqueous ammonia.

4. The method according to claim 1, wherein the solid base material for skin external application is used for cosmetics or pharmaceuticals.

5. The method according to claim 1, wherein the solid base material for skin external application is stick-shaped.