×

HOMOGENOUS ANTIBODY DRUG CONJUGATES VIA ENZYMATIC METHODS

  • US 20180360793A1
  • Filed: 05/22/2018
  • Published: 12/20/2018
  • Est. Priority Date: 06/12/2014
  • Status: Active Grant
First Claim
Patent Images

1. A method of making an antibody drug conjugate comprising an antibody specifically conjugated to a conjugate moiety comprising:

  • contacting an antibody composition comprising the antibody with the conjugate moiety in the presence of a transglutaminase under a condition sufficient to generate the antibody drug conjugate, wherein at least about 50% of the antibody in the antibody composition is glycosylated in the Fc-region, and wherein the conjugate moiety is conjugated to an endogenous acceptor glutamine residue on the antibody.

View all claims
  • 3 Assignments
Timeline View
Assignment View
    ×
    ×