Insulin Management

• US 20180366217A1
• Filed: 08/22/2018
• Published: 12/20/2018
• Est. Priority Date: 01/31/2014
• Status: Active Grant

• Current Assignee: Glytec LLC (Aseko, Inc.)
• Original Assignee: Aseko, Inc.
• Inventors: Booth, Robert C, Hebblewhite, Harry
• Granted Patent: US 10,811,133 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2005/14296 Pharmacokinetic models
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3327 Measuring
• CPC Class Codes: A61M 2205/35 Communication
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/507 Head Mounted Displays [HMD]
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: G16H 10/40 : for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: G16H 20/17 : delivered via infusion or injection
• CPC Class Codes: G16H 20/60 : relating to nutrition control, e.g. diets
• CPC Class Codes: G16H 40/67 : for remote operation
• CPC Class Codes: G16H 80/00 : ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring

Abstract

A dosing controller for administering insulin. The dosing controller includes a data processing device and non-transitory memory in communication with the data processing device. The dosing controller receives blood glucose measurements of a patient from the glucometer, receives patient information, selects a subcutaneous insulin treatment from a collection of subcutaneous insulin treatments based on the blood glucose measurements and the patient information, and executes the selected subcutaneous insulin treatment. Each blood glucose measurement is separated by a time interval and includes a blood glucose time associated with a time of measuring the blood glucose measurement.

Claims

1. A dosing controller comprising:

a data processing device; and

a non-transitory computer-readable medium in communication with the data processing device, the non-transitory computer-readable medium storing instructions that when executed on the data processing device cause the data processing device to perform operations comprising;

determining a total daily dose (TDD) of insulin for a current day based on all basal doses and bolus doses of insulin administered to the patient on an immediately previous day;

executing a subcutaneous treatment program configured to display on a screen in communication with the data processing device a graphical user interface, wherein the subcutaneous treatment program is configured to;

display, in the graphical user interface, a patient information input window and a blood glucose information window;

receive, in the patient information input window, patient information comprising;

a target blood glucose value of the patient; and

recommended boluses of insulin for administration to the patient at sequential time intervals throughout a day, wherein a value for the recommended boluses of insulin is based on the determined TDD of insulin for the current day;

receive, in the blood glucose information window, a blood glucose input for a blood glucose measurement of the patient; and

obtain a blood glucose time associated with measuring the blood glucose measurement;

determining a correction bolus based on the blood glucose measurement and the target blood glucose value; and

administering the recommended boluses and the correction bolus to the patient by transmitting the recommended boluses and the correction bolus from the data processing device to a dose administering system having a patient display at the sequential time interval that includes the blood glucose time for the blood glucose measurement of the patient, the patient display configured to display a first number of units of insulin corresponding to the recommended boluses and a second number of units of insulin corresponding to the correction bolus.

2. The dosing controller of claim 1, wherein the operations further comprise, after receiving the blood glucose input:

setting a countdown timer indicating a remaining time until a next blood glucose measurement of the patient based on the sequential time intervals,

wherein the subcutaneous treatment program is further configured to display, in the graphical user interface, the countdown timer.

3. The dosing controller of claim 2, wherein the subcutaneous treatment program is further configured to display, in the graphical user interface, a blood glucose due message when the remaining time until the next blood glucose measurement lapses indicating that the next blood glucose measurement for the patient is due.

4. The dosing controller of claim 1, wherein the recommended boluses comprise recommended equal-boluses and the number of sequential time intervals comprises:

six sequential time intervals, each spaced four hours apart;

or

four sequential time intervals, each spaced six hours apart.

5. The dosing controller of claim 4, wherein the blood glucose time for the blood glucose measurement of the patient is within one of:

a second sequential time interval, a third sequential time interval, a fourth sequential time interval, a fifth sequential time interval, or a sixth sequential time interval of the six sequential time intervals;

or

a first sequential time interval, a third sequential time interval, or a fourth sequential time interval of the four sequential time intervals.

6. The dosing controller of claim 4, wherein the operations further comprise:

determining for a given blood glucose time within a first sequential time interval of the four sequential time intervals or a second sequential time interval of the six sequential time intervals, a given blood glucose measurement that is within one of a plurality of target ranges of values;

determining an adjustment factor for adjusting a value of recommended equal-boluses to the patient based on the corresponding target range of values and the given blood glucose measurement;

retrieving a previous day'"'"'s value of recommended equal-boluses;

determining a new value of recommended equal-boluses by multiplying the adjustment factor times the previous day'"'"'s value of recommended equal-boluses; and

administering the new value of recommended equal-boluses to the patient by transmitting the new value of recommended equal-boluses from the data processing device to the dose administering system having the patient display at the sequential time intervals, the patient display configured to display a third number of units of insulin corresponding to the new value of recommended equal-boluses and trigger administration of the third number of units of insulin to the patient at each of the sequential time intervals.

7. The dosing controller of claim 6, wherein the plurality of target ranges of values comprises:

a first target range of values including blood glucose values less than a first configurable constant;

a second target range of values including blood glucose values greater than or equal to the first configurable constant and less than a low target blood glucose value of a target blood glucose range for the patient;

a third target range of values including blood glucose values greater than or equal to the low target blood glucose value and less than a high target blood glucose value of the target blood glucose range;

a fourth target range of values including blood glucose values greater than or equal to the high target blood glucose value and less than a second configurable constant;

a fifth target range of values including blood glucose values greater than or equal to the second configurable constant and less than a third configurable constant; and

a sixth target range of values including blood glucose values greater than or equal to the third configurable constant.

8. The dosing controller of claim 4, wherein the operations further comprise:

determining for a given blood glucose time within a second sequential time interval of the four sequential time intervals or a third sequential time interval of the six sequential time intervals, a given blood glucose measurement that is within one of a plurality of target ranges of values;

determining a basal dose adjustment factor for adjusting a current day recommended basal dose for administration to the patient based on the corresponding target range of values and the given blood glucose measurement;

retrieving a previous day recommended basal dose;

determining a new value of the current day recommended basal dose by multiplying the basal adjustment factor times the previous day recommended basal dose; and

administering the value of the current day'"'"'s recommended basal dose to the patient by transmitting the value of the current day'"'"'s recommended basal dose from the data processing device to the dose administering system having the patient display, the patient display configured to display a third number of units of insulin corresponding to the value of the current day'"'"'s recommended basal dose and trigger administration of the third number of units of insulin to the patient at a configurable frequency of one, two, or three times per day.

9. The dosing controller of claim 1, wherein determining the correction bolus based on the blood glucose measurement and the target blood glucose value comprises determining the correction bolus by calculating:

CB_x=(BG−

BG_Target)/CF;

wherein CB is the correction bolus, BG is the blood glucose measurement, BG_Target is the target blood glucose value of the patient, and CF is a correction factor.

10. The dosing controller of claim 9, wherein the operations further comprise:

determining the correction factor using the data processing device by calculating;

CF=CFR/TDD

wherein CF is the correction factor and CFR is a constant determined from a statistical correlation.

11. The dosing controller of claim 1, wherein the value for the recommended boluses of insulin is based on a bolus percentage of the TDD of insulin for the current day.

12. The dosing controller of claim 1, wherein the operations further comprise transmitting the recommended meal boluses and the correction bolus from the data processing device to a remote administration device, the remote administration device comprising a doser configured to:

automatically set or dial in and administer the first number of units of insulin corresponding to the recommended boluses to the patient at the sequential time interval that includes the blood glucose time for the blood glucose measurement of the patient; and

automatically set or dial in and administer the first number of units of insulin corresponding to the recommended boluses to the patient at the sequential time interval that includes the blood glucose time for the blood glucose measurement of the patient.