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ELECTROMECHANICAL LYSIS OF BACTERIAL PATHOGENS USING ION CONCENTRATION POLARIZATION

  • US 20180371400A1
  • Filed: 10/10/2017
  • Published: 12/27/2018
  • Est. Priority Date: 06/22/2017
  • Status: Active Grant
First Claim
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1. A method of lysing a cell membrane comprising the steps:

  • a. directing a fluid stream containing cells in a channel comprising an inlet and an outlet and defined, at least in part, by at least a first ion exchange membrane and at least a second ion exchange membrane, wherein the ion exchange membranes are juxtaposed and characterized by the same charge;

    b. applying an electric field across the channel at a voltage and duration sufficient to cause helical electroconvective vortex formation across the channel, thereby lysing the cell membranes of the cells;

    c. collecting a fluid stream comprising lysate; and

    d. isolating the lysate.

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