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YEAST STRAINS WITH REDUCED FATTY ALCOHOL OXIDASE ACTIVITY AND METHOD FOR THE PRODUCTION OF OMEGA-HYDROXY FATTY ACIDS AND DICARBOXYLIC ACIDS

  • US 20180371510A1
  • Filed: 08/13/2018
  • Published: 12/27/2018
  • Est. Priority Date: 12/12/2013
  • Status: Active Grant
First Claim
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1. A genetically engineered Yarrowia lipolytica cell, comprising:

  • a. a disrupted fatty alcohol oxidase encoding FAO1 YALI0B14014g gene; and

    b. at least one disrupted acyl-CoA oxidase encoding gene selected from the group consisting of;

    POX1, POX2, POX3, POX4, POX5, and POX6,wherein the engineered Yarrowia lipolytica cell has reduced fatty alcohol oxidase activity relative to a wild type Yarrowia lipolytica cell.

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