Profiling of Pathology Images for Clinical Applications
First Claim
1. A computerized method for classifying tissue characteristics in digital pathology images, comprising the steps of:
- (a) obtaining a digital pathology image of a tissue from a subject;
(b) dividing the digital pathology image into tiles;
(c) extracting primary features from the tiles in step (b), the primary features comprising shape, color, and texture features in the image;
(d) grouping similar tiles into a number of sets based on similarity of the primary features;
(e) selecting a representative tile from each set in step (d);
(f) extracting secondary features from selected tiles from step (e), wherein the secondary features refine primary features;
(g) assigning values to selected tiles, based on secondary features; and
(h) comparing the values in step (g) to values in a reference.
1 Assignment
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Accused Products
Abstract
Provided are automated (computerized) methods and systems for analyzing digitized pathology images in a variety of tissues potentially containing diseased or neoplastic cells. The method utilizes a coarse-to-fine analysis, in which an entire image is tiled and shape, color, and texture features are extracted in each tile, as primary features. A representative subset of tiles is determined within a cluster of similar tiles. A statistical analysis (e.g. principal component analysis) reduces the substantial number of “coarse” features, decreasing computational complexity of the classification algorithm. Afterwards, a fine stage provides a detailed analysis of a single representative tile from each group. A second statistical step uses a regression algorithm (e.g. elastic net classifier) to produce a diagnostic decision value for each representative tile. A weighted voting scheme aggregates the decision values from these tiles to obtain a diagnosis at the whole slide level.
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Citations
24 Claims
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1. A computerized method for classifying tissue characteristics in digital pathology images, comprising the steps of:
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(a) obtaining a digital pathology image of a tissue from a subject; (b) dividing the digital pathology image into tiles; (c) extracting primary features from the tiles in step (b), the primary features comprising shape, color, and texture features in the image; (d) grouping similar tiles into a number of sets based on similarity of the primary features; (e) selecting a representative tile from each set in step (d); (f) extracting secondary features from selected tiles from step (e), wherein the secondary features refine primary features; (g) assigning values to selected tiles, based on secondary features; and (h) comparing the values in step (g) to values in a reference. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 17, 18, 19, 20, 23, 24)
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15-16. -16. (canceled)
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21-22. -22. (canceled)
Specification