MODULAR TISSUE SCAFFOLDS

• US 20190000628A1
• Filed: 03/26/2018
• Published: 01/03/2019
• Est. Priority Date: 02/28/2011
• Status: Active Grant

• Current Assignee: Depuy Synthes Products Incorporated (Johnson & Johnson)
• Original Assignee: Depuy Synthes Products Incorporated (Johnson & Johnson)
• Inventors: Hollister, Scott J., Feinberg, Stephen E., Murphy, William L., Jongpaiboonkit, Leenaporn, Adox, James R., Migneco, Francesco
• Granted Patent: US 10,500,053 B2
• Time in Patent Office: Days
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/2803 for mandibular reconstruction temporo-mandibular joints A61F2/3099; bone plates for the jaw A61B17/8071
• CPC Class Codes: A61F 2/2875 Skull or cranium A61F2/2803 and A61F2/3099 take precedence
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30331 made by longitudinally pushing a protrusion into a complementarily-shaped recess, e.g. held by friction fit
• CPC Class Codes: A61F 2002/30387 Dovetail connection
• CPC Class Codes: A61F 2002/30451 soldered or brazed or welded
• CPC Class Codes: A61F 2002/305 Snap connection
• CPC Class Codes: A61F 2002/30604 modular
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30948 using computerized tomography, i.e. CT scans
• CPC Class Codes: A61F 2002/30952 using CAD-CAM techniques or NC-techniques
• CPC Class Codes: A61F 2002/30962 using stereolithography
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing

Abstract

Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.

Claims

1. A tissue scaffold comprising a first module that is biocompatible and degradable when implanted into a vertebrate, long bone, mandible or cranium,

wherein the first module is designed to couple to a second module that is biocompatible and degradable when implanted into a mammal, and

wherein the first module comprises an A connector designed to couple to a B connector present on the second module.

2. The tissue scaffold of claim 1, further comprising the second module, wherein the second module is joined to the first module by coupling the B connector of the second module to the A connector of the first module.

3. The tissue scaffold of claim 1, comprising at least one feature selected from the group consisting of:

(i) the A connector is integral to the first module and the B connector is integral to the second module;

(ii) the A connector is identical to the B connector;

(iii) the A connector is not identical to the B connector;

(iv) the A connector and B connector are dovetail connectors;

(v) the A connector and B connector are elliptical dovetail connectors; and

(vi) the tissue scaffold comprises one or more additional modules, wherein each additional module is joined to the first or prior module by coupling the B connectors of the additional modules to the A connectors of the first and prior modules, and wherein the number of modules is determined by the size of a gap in the vertebrate, long bone, mandible or cranium.