NOVEL a4B7 PEPTIDE DIMER ANTAGONISTS
First Claim
Patent Images
1. A method for increasing potency for α
- 4β
7 of a peptide molecule according to SEQ ID NO;
39, comprising forming a dimer molecule through a C- or N-terminal dimerization.
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Abstract
The invention relates to disulfide-rich dimer molecules which inhibit binding of α4β7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, and show high selectivity against α4β1 binding.
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1 Claim
-
1. A method for increasing potency for α
- 4β
7 of a peptide molecule according to SEQ ID NO;
39, comprising forming a dimer molecule through a C- or N-terminal dimerization.
- 4β
Specification