Anti-GITR Antibodies and Methods of Use Thereof
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Abstract
The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
8 Citations
239 Claims
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1-205. -205. (canceled)
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206. An isolated nucleic acid molecule encoding an antibody that specifically binds to human GITR, wherein the human GITR comprises residues 26-241 of SEQ ID NO:
- 701, and wherein the antibody binds to at least one residue within the amino acid sequence set forth by residues 60-63 of SEQ ID NO;
701. - View Dependent Claims (207, 208, 209, 210, 211)
- 701, and wherein the antibody binds to at least one residue within the amino acid sequence set forth by residues 60-63 of SEQ ID NO;
- 212. A host cell comprising the isolated nucleic acid molecule of 206.
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214. An isolated nucleic acid molecule encoding an antibody that specifically binds to human GITR, wherein the antibody comprises:
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(a) a heavy chain variable region (VH) complementarity determining region (CDR) 1 comprising the amino acid sequence of X1YX2MX3 (SEQ ID NO;
1), whereinX1 is D, E, G or A; X2 is A, V, L, I, P, F, M or Y; and X3 is Y, G, N, Q, S, T, C, W, F or H; (b) a VH CDR2 comprising the amino acid sequence of X1IX2X3X4SGX5X6X7YX8QKFX9X10 (SEQ ID NO;
2), whereinX1 is V, A, L, I, P, F, M or T; X2 is R, K, H, Q or A; X3 is T, G, N, Q, S, C, W, Y, V, I or P; X4 is Y, G, N, Q, S, T, C, W, F, H, or A; X5 is D, E, G or A; X6 is V, A, L, I, P, F, M or T; X7 is T, G, N, Q, S, C, W, Y, V, I, P or A; X8 is N, G, Q, S, T, C, W, Y or A; X9 is K, R, H, Q or A; and X10 is D, E, G or A; (c) a VH CDR3 comprising the amino acid sequence of SGTVRGX1X2X3 (SEQ ID NO;
3), whereinX1 is F, A, V, L, I, P, M, Y, W, H or S; X2 is A, or D; and X3 is Y, G, N, Q, S, T, C, W, F, H or V; (d) a light chain variable region (VL) CDR1 comprising the amino acid sequence of KSSQSX1X2X3X4X5X6X7KX8YLX9 (SEQ ID NO;
4), wherein;X1 is L, A, V, I, P, F or M; X2 is L, A, V, I, P, F, M or 5; X3 is N, G, Q, S, T, C, W, Y or A; X4 is S, G, N, Q, T, C, W, Y or A; X5 is G, N, Q, S, T, C, W, Y or A; X6 is N, G, Q, S, T, C, W, Y or A; X7 is Q, G, N, S, T, C, W, Y or A; X8 is N, G, Q, S, T, C, W, Y or A; and X9 is T, G, N, Q, S, C, W, Y, V, I or A; (e) a VL CDR2 comprising the amino acid sequence of X1ASTRX2X3 (SEQ ID NO;
5), wherein;X1 is W, G, N, Q, S, T, C, Y, F, H or A; X2 is E, D or A; and X3 is S, G, N, Q, T, C, W, Y or A; and (f) a VL CDR3 comprising the amino acid sequence of QX1X2YX3X4PYT (SEQ ID NO;
6), wherein;X1 is N, G, Q, S, T, C, W or Y; X2 is D, E or Y; and X3 is S, G, N, Q, T, C, W, Y or A; and X4 is Y, G, N, Q, 5, T, C, W, F, H, L, or A. - View Dependent Claims (215, 216, 217, 218, 219, 220, 221)
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- 222. A host cell comprising the isolated nucleic acid molecule of 214.
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224. A host cell comprising (i) a first nucleic acid encoding a VH comprising a VH CDR1 comprising the amino acid sequence of DYAMY (SEQ ID NO:
- 13), a VH CDR2 comprising the amino acid sequence of VIRTYSGDVTYNQKFKD (SEQ ID NO;
14), and VH CDR3 comprising the amino acid sequence of SGTVRGFAY (SEQ ID NO;
15) and (ii) a second nucleic acid encoding a VL comprising a VL CDR1 comprising the amino acid sequence of KSSQSLLNSGNQKNYLT (SEQ ID NO;
16), a VL CDR2 comprising the amino acid sequence of WASTRES (SEQ ID NO;
17), and a VL CDR3 comprising the amino acid sequence of QNDYSYPYT (SEQ ID NO;
18). - View Dependent Claims (225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239)
- 13), a VH CDR2 comprising the amino acid sequence of VIRTYSGDVTYNQKFKD (SEQ ID NO;
Specification