OCULAR IMPLANT DELIVERY SYSTEM AND METHODS THEREOF

• US 20190030302A1
• Filed: 05/29/2018
• Published: 01/31/2019
• Est. Priority Date: 04/07/2001
• Status: Active Grant

• Current Assignee: Glaukos Corporation
• Original Assignee: Glaukos Corporation
• Inventors: Haffner, David Steven, Smedley, Gregory T., Tu, Hosheng, Niksch, Barbara A., Hill, Richard A., Bergheim, Olav B.
• Granted Patent: US 10,828,473 B2
• Time in Patent Office: Days
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 27/00 Drainage appliance for wounds or the like , i.e. wound drains, implanted drains negative pressure wound therapy devices A61M1/90; implements for holding wound open A61B17/02 ; middle ear drainage A61F11/202

Abstract

Systems and methods for treating ocular disorders are disclosed. One system has a delivery instrument, with a non-linear axis, configured to be inserted into an anterior chamber of an eye and moved to a location proximate a physiologic outflow pathway of the eye. The delivery instrument carries an implant that has a distal end sized for insertion into tissue such that aqueous humor drains from the anterior chamber to the physiologic outflow pathway. One method involves inserting a non-linear portion of a delivery device into the anterior chamber to position an implant within the eye. Another method involves using a delivery device with a curved distal portion to implant an implant at a location communicating with the physiologic outflow pathway. The delivery can be through a corneal incision and the implant can comprise a drug.

Claims

1-4. -4. (canceled)

5. A method of treating glaucoma comprising:

forming an incision in a cornea of an eye;

inserting a delivery applicator through the incision in the cornea and across at least a portion of an anterior chamber of the eye in an ab interno manner, the delivery applicator comprising an elongate member having a distal end portion configured to retain a trabecular stenting device therein prior to implantation,

wherein the delivery applicator has a curved distal portion;

guiding the trabecular stenting device out of the elongate member of the delivery applicator such that a first portion of the trabecular stenting device is positioned in Schlemm'"'"'s canal of the eye and a second portion of the trabecular stenting device is positioned in the anterior chamber; and

removing the delivery applicator from the eye,

wherein the trabecular stenting device is made of biocompatible titanium alloy material,

wherein the second portion of the trabecular stenting device comprises an inlet,

wherein the first portion of the trabecular stenting device comprises an upper curved surface and a lower curved surface which defines a trough.

6. The method of claim 5, wherein guiding the trabecular stenting device comprises pushing the trabecular stenting device out of the elongate member.

7. The method of claim 5, wherein the elongate member of the delivery applicator comprises a wire.

8. The method of claim 5, wherein the distal end portion of the elongate member is flexible.

9. The method of claim 5, wherein the trabecular stenting device is configured to facilitate fluid flow in both directions along Schlemm'"'"'s canal.

10. The method of claim 5, wherein the trabecular stenting device comprises multiple ports.

11. A method of treating glaucoma comprising:

forming an incision in a cornea of an eye;

inserting a delivery applicator through the incision in the cornea and into an anterior chamber of the eye in an ab interno manner, the delivery applicator comprising an elongate member having a distal end portion configured to retain a trabecular stenting device therein prior to implantation,

wherein the distal end portion of the elongate member is curved;

guiding the trabecular stenting device out of the elongate member of the delivery applicator such that a first portion of the trabecular stenting device is positioned in Schlemm'"'"'s canal of the eye and a second portion of the trabecular stenting device is positioned in the anterior chamber; and

removing the delivery applicator from the eye,

wherein the second portion of the trabecular stenting device comprises a proximal inlet,

wherein the first portion of the trabecular stenting device comprises an outer curved surface and an inner curved surface which defines a trough.

12. The method of claim 11, wherein guiding the trabecular stenting device comprises pushing the trabecular stenting device out of the elongate member.

13. The method of claim 11, wherein the elongate member of the delivery applicator comprises a wire.

14. The method of claim 11, wherein the distal end portion of the elongate member is flexible.

15. The method of claim 11, wherein the trabecular stenting device is configured to facilitate fluid flow in both directions along Schlemm'"'"'s canal.

16. The method of claim 11, wherein the trabecular stenting device comprises multiple ports.

17. A system comprising:

a trabecular stenting device comprising a biocompatible material,

wherein the biocompatible material comprises a titanium alloy,

wherein the trabecular stenting device comprises a proximal end portion and a main body portion,

wherein the proximal end portion is adapted to be positioned in an anterior chamber of an eye upon implantation,

wherein the main body portion is adapted to be positioned within Schlemm'"'"'s canal of the eye upon implantation,

wherein the proximal end portion comprises an inlet,

wherein the main body portion comprises at least one upper curved surface and at least one lower curved surface which defines an open face channel; and

a delivery apparatus adapted to hold the trabecular stenting device of the delivery apparatus prior to implantation and to deploy the trabecular stenting device to facilitate implantation of the trabecular stenting device,

wherein the delivery apparatus comprises a handpiece and an elongate tip connected to a distal end of the handpiece,

wherein a distal portion of the elongate tip is configured to be placed through a corneal incision and into an anterior chamber of the eye and then advanced near an implantation location, and

wherein the distal portion of the elongate tip of the delivery apparatus is curved.

18. The system of claim 17, wherein the main body portion is angled relative to the proximal end portion.

19. The system of claim 17, wherein the delivery apparatus comprises a push-pull type plunger.

20. The system of claim 17, wherein the distal portion of the elongate tip is flexible.

21. The system of claim 17, wherein the trabecular stenting device comprises multiple ports.

22. The system of claim 17, wherein the delivery apparatus comprises a release mechanism.

23. The system of claim 17, wherein the trabecular stenting device is configured to facilitate fluid flow in both directions along Schlemm'"'"'s canal.

24. The system of claim 17, wherein the trabecular stenting device comprises a heparin coating.