Method of Reducing the Likelihood of Skin Cancer in an Individual Human Being

• US 20190038680A1
• Filed: 10/15/2018
• Published: 02/07/2019
• Est. Priority Date: 02/04/2011
• Status: Active Grant

• Current Assignee: Seed Health, Inc.
• Original Assignee: Joseph E. Kovarik
• Inventors: Kovarik, Joseph E.
• Granted Patent: US 10,314,866 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 2035/11 Medicinal preparations comprising living procariotic cells
• CPC Class Codes: A61K 31/58 containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin digitoxin A61K31/7048
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 35/74 Bacteria therapeutic use of a bacterial protein A61K38/00
• CPC Class Codes: A61K 38/1709 from mammals
• CPC Class Codes: A61K 38/1758 p53

Abstract

Compositions, systems and methods of improving the health of the microbiome of an individual'"'"'s skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome.

Claims

1. A method of reducing the likelihood of skin cancer in an individual human being, said method comprising:

administering a therapeutically effective amount of a bacterial formulation comprising Nitrosomonas eutropha adapted to produce p53, said bacterial formulation comprising a lotion, ointment or gel adapted to be rubbed onto a region of an individual'"'"'s skin;

administering to the individual'"'"'s skin a prebiotic that comprises a nutrient source for the Nitrosomonas eutropha;

wherein said prebiotic is assimilated by the bacteria formulation.

2. The method as set forth in claim 1, wherein the region of the skin is the scalp.

3. The method as set forth in claim 1, wherein the bacterial formulation further includes Propionibacterium bacteria.

4. The method as set forth in claim 1, further comprising administering to the skin an extract derived from a helminth selected from the group consisting of Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus, and Trichinella spiralis.

5. The method as set forth in claim 1, wherein the bacterial formulation includes at least one arabinogalactan.

6. The method as set forth in claim 1, wherein the bacterial formulation includes L. johnsonii.

7. The method as set forth in claim 1, wherein the bacterial formulation comprises a topical lotion that comprises a mixture of Lactobacillus johnsonii, and Bifidobacterium lognum bacteria.

8. The method as set forth in claim 7, wherein the topical lotion is administered to an individual'"'"'s skin as a probiotic bacteriotherapy to treat skin diseases selected from the group consisting of eczema, atopic dermatitis, acne, allergic inflammation, and skin hypersensitivity.

9. The method as set forth in claim 7, wherein the topical lotion is administered to an individual'"'"'s skin as a probiotic bacteriotherapy to treat UV-induced skin damage.

10. The method as set forth in claim 1, wherein at least some bacteria in the bacterial formulation have been modified by using a using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1 (Cpf1) system to remove a virulence factor of the at least some bacteria.

11. The method as set forth in claim 7, wherein the topical lotion comprises a population of pre-selected bacteria comprising non-pathogenic bacteria.

12. The method as set forth in claim 7, wherein the topical lotion is administered to an individual'"'"'s skin to establish a resident bacterial population on the individual'"'"'s skin in order to enhance the overall health of the individual'"'"'s skin.

13. The method as set forth in claim 1, wherein the bacterial formulation further comprises UV protectant chemicals.

14. The method as set forth in claim 1, wherein the bacterial formulation comprises proteins produced by said bacterial formulation.

15. The method as set forth in claim 1, wherein the bacterial formulation enhances one of skin hydration, reduction of epidermal thickening, transepidermal water loss and protection of skin from harmful UV radiation.

16. The method as set forth in claim 1, wherein the bacterial formulation comprises a bifidobacterium strain.

17. A method of reducing the likelihood of skin cancer in an individual human being, said method comprising:

administering a therapeutically effective amount of a bacterial formulation comprising Nitrosomonas eutropha adapted to produce p53, said bacterial formulation including a bifidobacterium strain and UV protectant chemicals.

18. The method as set forth in claim 17, wherein the bacterial formulation further includes Propionibacterium bacteria.

19. A method of reducing the likelihood of skin cancer in an individual human being, said method comprising:

administering a therapeutically effective amount of a bacterial formulation comprising Nitrosomonas eutropha adapted to produce p53, said bacterial formulation comprising Lactobacillus johnsonii.

20. The method as set forth in claim 19, wherein the bacterial formulation further includes Propionibacterium bacteria modified by using a using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1 (Cpf1) system to remove a virulence factor.