ELECTROCHEMICAL METABOLIC ACTIVITY DETECTING DEVICE
First Claim
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1. A method for detecting metabolic activity of target cells in a sample, the method comprising:
- concentrating the target cells in a nanoliter well;
introducing into the well a reporter compound that exhibits a change in electrochemical state in response to metabolic activity of the target cells;
determining any change in an electrochemical state of contents in the well over a time period; and
detecting metabolic activity or viability of the target cells based on a determined change in the electrochemical state of contents in the well.
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Abstract
Methods and devices for detecting metabolic activity of target cells in a sample. The target cells are concentrated in a nanoliter well having a microfilter. A reporter compound that exhibits a change in electrochemical state in response to metabolic activity of the target cells is introduced. Metabolic activity or viability of the target cells is detected based on a determined change in the electrochemical state of contents in the well.
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Citations
21 Claims
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1. A method for detecting metabolic activity of target cells in a sample, the method comprising:
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concentrating the target cells in a nanoliter well; introducing into the well a reporter compound that exhibits a change in electrochemical state in response to metabolic activity of the target cells; determining any change in an electrochemical state of contents in the well over a time period; and detecting metabolic activity or viability of the target cells based on a determined change in the electrochemical state of contents in the well. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 21)
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10. A device comprising:
a nanoliter well comprising; an inlet for receiving the sample; a microfilter for inhibiting the target cells from exiting the well through an outlet of the well; and electrodes in the well for sensing an electrochemical state of contents in the well. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. (canceled)
Specification