ANTI-MICROBIAL ARTICLES AND METHODS OF USING SAME

• US 20190054202A1
• Filed: 11/10/2016
• Published: 02/21/2019
• Est. Priority Date: 11/13/2015
• Status: Active Grant

• Current Assignee: Solventum Intellectual Properties Company (Solventum Corp.)
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Yu, Ta-Hua, Demirgoz, Done, Liu, Junkang J., Veeraraghavan, Badri, Stepanova, Narina
• Granted Patent: US 10,639,395 B2
• Time in Patent Office: Days
• CPC Class Codes: A61L 15/18 containing inorganic materials
• CPC Class Codes: A61L 15/42 Use of materials characterised by their function or physical properties liquid bandages A61L26/00
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/608 having two or more layers
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers

Abstract

An article having anti-microbial effect is provided. The article includes an occlusive layer; a substrate having two opposing major surfaces, wherein one opposing major surface is a nanostructured surface; a metal oxide layer, wherein the nanostructured surface is coated with the metal oxide layer and the metal oxide layer comprises a metal oxide; and a metal layer overlaying the metal oxide layer.

Claims

1. An article comprising:

an occlusive layer;

a substrate having two opposing major surfaces, wherein one opposing major surface is a nanostructured surface;

a metal oxide layer, wherein the nanostructured surface is coated with the metal oxide layer and the metal oxide layer comprises a metal oxide; and

a metal layer overlaying the metal oxide layer.

3. The article of claim 1, wherein the metal layer adjourns the metal oxide layer.

4. The article of claim 1, wherein the metal layer is discontinuous or patterned.

5. The article of claim 1, wherein the metal oxide layer is in direct contact with one opposing major surface of the substrate and the metal layer is in direct contact with the other opposing major surface of the substrate.

6. The article of claim 1, wherein the nanostructured surface comprises an anisotropic nanostructure.

7. The article of claim 1, wherein the metal oxide is selected from silver oxide, copper oxide, gold oxide, platinum oxide, zinc oxide, magnesium oxide, titanium oxide, chromium oxide and combinations thereof.

8. The article of claim 7, wherein the metal oxide is silver oxide.

9. The article of claim 8, wherein the silver oxide is Ag₂O.

10. The article of claim 1, wherein the metal layer comprises a metal and the metal is selected from zinc, magnesium, aluminum, iron, calcium, tin, copper, titanium, chromium, nickel and alloys thereof.

11. The article of claim 1, wherein the metal oxide layer is formed by vapor deposition.

12. The article claim 1, wherein the article exhibits a more than 4 log reduction of bacterial growth within 7 days.

13. The article of claim 1, wherein Ag⁺ release concentration of the article is more than 3.5 ppm.

14. The article of claim 1, wherein the article is capable of generating at least one electrical current when introduced to an electrolytic solution.

15. A method of use the article of claim 1, comprising of

providing the article of claim 1;

and

applying the article to a subject;

wherein the article exhibits a more than 4 log reduction of bacterial growth within 7 days.

2. An article comprising:

an occlusive layer;

a substrate having two opposing major surfaces, wherein one opposing major surface is a nanostructured surface;

a metal layer, wherein the nanostructured surface is coated with the metal layer; and

a metal oxide layer overlaying the metal layer, wherein the metal oxide layer comprises a metal oxide.