INTEGRATED ORGAN-ON-CHIP SYSTEMS AND APPLICATIONS OF THE SAME
First Claim
1. A microclinical analyzer usable for analysis of one or more bio-objects, each bio-object including an organ or a group of cells, comprising:
- (a) a fluidic network having a plurality of fluidic switches, a plurality of fluidic paths in fluid communication with the plurality of fluidic switches, and one or more on-chip pumps coupled to corresponding fluidic paths;
(b) a sensor array coupled to the fluidic network; and
(c) a microcontroller for individually controlling the plurality of fluidic switches and the one or more on-chip pumps of the fluidic network as so to operably and selectively deliver an effluent of at least one bio-object to the sensor array for detecting properties of the effluent, or to a predetermined outlet destination.
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Accused Products
Abstract
A microclinical analyzer usable for analysis of one or more bio-objects, each bio-object including an organ or a group of cells includes a fluidic network having a plurality of fluidic switches, a plurality of fluidic paths in fluid communication with the plurality of fluidic switches, and one or more on-chip pumps coupled to corresponding fluidic paths; a sensor array coupled to the fluidic network; and a microcontroller for individually controlling the plurality of fluidic switches and the one or more on-chip pumps of the fluidic network as so to operably and selectively deliver an effluent of at least one bio-object to the sensor array for detecting properties of the effluent, or to a predetermined outlet destination.
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Citations
20 Claims
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1. A microclinical analyzer usable for analysis of one or more bio-objects, each bio-object including an organ or a group of cells, comprising:
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(a) a fluidic network having a plurality of fluidic switches, a plurality of fluidic paths in fluid communication with the plurality of fluidic switches, and one or more on-chip pumps coupled to corresponding fluidic paths; (b) a sensor array coupled to the fluidic network; and (c) a microcontroller for individually controlling the plurality of fluidic switches and the one or more on-chip pumps of the fluidic network as so to operably and selectively deliver an effluent of at least one bio-object to the sensor array for detecting properties of the effluent, or to a predetermined outlet destination. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method for analyzing a plurality of bio-objects, each bio-object including an organ or a group of cells, comprising the steps of:
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(a) providing a plurality of fluids; (b) providing a fluidic network configured to be in fluid communication with the plurality of bio-objects and the plurality of fluids, wherein the fluidic network comprises a plurality of fluidic switches, one or more on-chip pumps and a plurality of fluidic paths connected therebetween; and (c) controlling the plurality of fluidic switches and the one or more on-chip pumps to selectively and individually perfuse at least one of the plurality of bio-objects with at least one of the plurality of fluids at a predetermined perfusion flow rate and deliver an effluent of the at least one bio-object responsive to the perfusion to a predetermined outlet destination for analysis, recirculation, waste exhaust, or input to other bio-objects of the plurality of bio-objects. - View Dependent Claims (17, 18, 19, 20)
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Specification