Targeting of Human Glucocorticoid Receptor Beta in Cancer
First Claim
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1. A composition comprising a peptide nucleic acid (PNA) consisting of the sequence TGCCATACACAGTAT [SEQ ID NO:
- 1].
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Abstract
A peptide nucleic acid (PNA) referred to herein as Sweet-P, compositions comprising the methods of making the same, mid methods of using the same, are described.
1 Citation
29 Claims
- 1. A composition comprising a peptide nucleic acid (PNA) consisting of the sequence TGCCATACACAGTAT [SEQ ID NO:
-
8. A peptide nucleic acid (PNA) consisting of the sequence TGCCATACACAGTAT [SEQ ID NO:
- 1].
-
10. A method of modulating GRβ
- expression in cells, the method comprising;
administering to cells an effective amount of an agent capable of blocking miR144 binding to GRβ
, and modulating GRβ
expression in the cells. - View Dependent Claims (11, 12, 13)
- expression in cells, the method comprising;
-
14. A method of treating a GRβ
- -related disease, the method comprising;
administering an effective amount of an agent to a subject in need thereof, wherein the effective amount of the agent blocks miR144 binding to GRβ
in the subject, and treating a GRβ
-related disease in the subject. - View Dependent Claims (15, 16, 17, 18, 19)
- -related disease, the method comprising;
-
29. A kit for preparing a pharmaceutical composition, the kit comprising:
-
a first container housing a peptide nucleic acid (PNA) consisting of the sequence TGCCATACACAGTAT [SEQ ID NO;
1]; anda second container housing an O-linker or a modified tat protein consisting of the amino acid sequence VQRKRQKLMP [SEQ ID NO;
2].
-
Specification