COSMETIC COMPOSITION FOR WRINKLE REDUCTION CONTAINING GYPENOSIDE ISOLATED FROM GYNOSTEMMA PENTAPHYLLUM

• US 20190110980A1
• Filed: 06/10/2016
• Published: 04/18/2019
• Est. Priority Date: 06/11/2015
• Status: Active Grant

• Current Assignee: Celltrion Incorporated (Celltrion Healthcare Company Limited)
• Original Assignee: Celltrion Incorporated (Celltrion Healthcare Company Limited)
• Inventors: Park, Young Jun, Yu, Kee Won, Kim, Jae Hun, Kim, Yeon Sook, Lee, Seung Ki, Lim, Joo Hyuck, Kim, Jong Mook, Choi, Chi Ho, Kim, Ju Yeon, Kim, Jung Yun, M oon, Sung Ho
• Granted Patent: US 11,007,136 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 2800/782 Enzyme inhibitors; Enzyme antagonists
• CPC Class Codes: A61K 8/63 Steroids; Derivatives thereof
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The present invention relates to a cosmetic composition for wrinkle reduction comprising, as an active ingredient, a Gynostemma pentaphyllum gypenoside fraction and, more specifically, to a cosmetic composition for wrinkle reduction, wherein the Gynostemma pentaphyllum gypenoside fraction includes at least one gypenoside selected from the group consisting of gypenoside UL1, gypenoside UL2, gypenoside UL3, gypenoside UL4, gypenoside UL5, gypenoside UL6, and gypenoside UL7.

Claims

1. A cosmetic position for wrinkle reduction comprising a Gynostemma pentaphyllum gypenoside fraction.

2. The cosmetic composition for wrinkle reduction according to claim 1, characterized in that the Gynostemma pentaphyllum gypenoside fraction comprises at least one gypenoside selected from the group consisting of gypenoside UL1, gypenoside UL2, gypenoside UL3, gypenoside UL4, gypenoside UL5, gypenoside UL6 and gypenoside UL7:

in the above description,

the gypenoside UL1 means (23ξ

)-3β

,20β

,21α

-trihydroxy-19-oxo-21,23-epoxy-dammar-24-ene-3-O-[α

-L-rhamnopyranosyl (1→

2)]-α

-L-arabinopyranoside;

the gypenoside UL2 means (23ξ

)-3β

,20β

,21α

-trihydroxy-19-oxo-21,23-epoxy-dammar-24-ene-3-O-[β

-D-glucopyranosyl (1→

3)]-α

-L-arabinopyranoside;

the gypenoside UL3 means (23ξ

)-3β

,20β

,21α

-trihydroxy-21,23-epoxy-dammar-24-ene-3-O-[α

-L-rhamnopyranosyl (1→

2)][β

-D-xylopyranosyl (1→

3)]-α

-L-arabinopyranoside;

the gypenoside UL4 means (23ξ

)-3β

,20β

,21α

-trihydroxy-19-oxo-21,23-epoxy-dammar-24-ene-3-O-[α

-L-rhamnopyranosyl (1→

2)][β

-D-xylopyranosyl (1→

3)]-α

-L-arabinopyranoside;

the gypenoside UL5 means (23ξ

)-3β

,20β

,21α

-trihydroxy-19-oxo-21,23-epoxy-dammar-24-ene-3-O-[α

-L-rhamnopyranosyl (1→

2)][β

-D-glucopyranosyl (1→

3)]-α

-L-arabinopyranoside;

the gypenoside UL6 means 3β

,20S,21-trihydroxy-19-oxo-dammar-24-ene-3-O-[α

-L-rhamnopyranosyl (1→

2)]{[β

-D-xylopyranosyl (1→

6)][β

-D-glucopyranosyl (1→

3)]}-α

-L-arabinopyranoside-21-O-β

-D-glucopyranoside, and

the gypenoside UL7 means 3β

,20S-dihydroxy-21-carboxyl-dammar-24-ene-3-O-[ϵ

-L-rhamnopyranosyl (1→

2)]{[β

-D-xylopyranosyl (1→

6)][β

D-glucopyranosyl (1→

3)]}-α

-L-arabinopyranoside-21-O-β

-D-glucopyranoside.

3. The cosmetic composition for wrinkle reduction according to claim 1, characterized in that the Gynostemma pentaphyllum gypenoside fraction is comprised by 0.001 to 30 wt % compared to the total weight of a composition.

4. The cosmetic composition for wrinkle reduction according to claim 2, characterized in that the Gynostemma pentaphyllum gypenoside fraction contains comprises at least one of the gypenoside UL4 and the gypenoside UL5 by 20 to 30 wt % compared to the total weight of the fraction.

5. The cosmetic composition for wrinkle reduction according to claim 1, characterized in that the wrinkle is a tr sp ent wrinkle.

12. A method for reducing a wrinkle by using a cosmetic composition of claim 1.

6. A cosmetic composition for wrinkle reduction containing comprising at least one gypenoside represented by a following Formula I:

7. The cosmetic composition for wrinkle reduction according to claim 6, characterized in that the composition comprises at least one gypenoside selected from the group consisting of gypenoside UL1, gypenoside UL2, gypenoside UL3, gypenoside UL4, gypenoside UL5, gypenoside UL6 and gypenoside UL7:

in the above description,

the gypenoside UL1 means (23ξ

)-3β

,20β

,21α

-trihydroxy-19-oxo-21,23-epoxy-dammar-24-ene-3-O-[α

-L-rhamnopyranosyl (1→

2)]-α

-L-arabinopyranoside;

the gypenoside UL2 means (23ξ

)-3β

,20β

,21α

-trihydroxy-19-oxo-21,23-epoxy-dammar-24-ene-3-O-[β

-D-glucopyranosyl (1→

3)]-α

-L-arabinopyranoside;

the gypenoside UL3 means (23ξ

)-3β

,20β

,21α

-trihydroxy-21,23-epoxy-dammar-24-ene-3-O-[α

-L-rhamnopyranosyl (1→

2)][β

-D-xylopyranosyl (1→

3)]-α

-L-arabinopyranoside;

the gypenoside UL4 means (23ξ

)-3β

,20β

,21α

-trihydroxy-19-oxo-21,23-epoxy-dammar-24-ene-3-O-[α

-L-rhamnopyranosyl (1→

2)][β

-D-xylopyranosyl (1→

3)]-α

-L-arabinopyranoside;

the gypenoside UL5 means (23ξ

)-3β

,20β

,21α

-trihydroxy-19-oxo-21,23-epoxy-dammar-24-ene-3-O-[α

-L-rhamnopyranosyl (1→

2)][β

-D-glucopyranosyl (1→

3)]-α

-L-arabinopyranoside;

the gypenoside UL6 means 3β

,20S,21-trihydroxy-19-oxo-dammar-24-ene-3-O-[α

-L-rhamnopyranosyl (1→

2)]{[β

-D-xylopyranosyl (1→

6)][β

-D-glucopyranosyl (1→

3)]}-α

-L-arabinopyranoside-21-O-β

-D-glucopyranoside, and

the gypenoside UL7 means 3β

,20S-dihydroxy-21-carboxyl-dammar-24-ene-3-O-[ϵ

-L-rhamnopyranosyl (1→

2)]{[β

-D-xylopyranosyl (1→

6)][β

D-glucopyranosyl (1→

3)]}-α

-L-arabinopyranoside-21-O-β

-D-glucopyranoside.

8. The cosmetic composition for wrinkle reduction according to claim 6, characterized in that the gypenoside is isolated from Gynostemma pentaphyllum.

9. The cosmetic composition for wrinkle reduction according to claim 6, characterized in that the composition comprises the gypenoside by 0.0001 to 30 wt % compared to the total weight of the composition.

10. The cosmetic composition for wrinkle reduction according to claim 7, characterized in that the composition comprises at least one of the gypenoside UL4 and the gypenoide UL5 by 0.0002 to 9 wt % compared to the total weight of the composition.

11. The cosmetic composition for wrinkle reduction according to claim 6, characterized in that the wrinkle is a transparent wrinkle.