SPHINGOSINE KINASE TYPE 1 INHIBITORS AND USES THEREOF

• US 20190111007A1
• Filed: 11/26/2018
• Published: 04/18/2019
• Est. Priority Date: 04/29/2008
• Status: Active Grant

• Current Assignee: Enzo Therapeutics Incorporated (Enzo Biochem Incorporated), Virginia Commonwealth University
• Original Assignee: Enzo Therapeutics Incorporated (Enzo Biochem Incorporated), Virginia Commonwealth University
• Inventors: Spiegel, Sarah, Zipkin, Robert Elliot, Adams, Jeffrey Kroll
• Granted Patent: US 10,456,370 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/40 having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: C07C 215/28 and containing six-membered aromatic rings
• CPC Class Codes: C07C 217/64 with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
• CPC Class Codes: C07C 233/18 having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
• CPC Class Codes: C07C 323/32 having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
• CPC Class Codes: C07D 263/06 with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
• CPC Class Codes: C07D 295/092 with aromatic radicals attached to the chain

Abstract

Provided are inhibitors of sphingosine kinase Type I and their use in the treatment of asthma, among other indications and diseases.

Claims