INHIBITION OF INFLAMMATORY CYTOKINE PRODUCTION BY CHOLINERGIC AGONISTS AND VAGUS NERVE STIMULATION
First Claim
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1. A method for treating an inflammatory disorder in a patient, the method comprising:
- evoking a sustained decrease in a level of one or more pro-inflammatory cytokines over an untreated state in the patient without increasing the activity of a humoral anti-inflammatory mediator by directly electrically stimulating the patient'"'"'s vagus nerve from an electrode on the patient'"'"'s vagus nerve, wherein the patient'"'"'s heart rate remains stable for 10 minutes after the vagus nerve is electrically stimulated.
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Abstract
A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.
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18 Claims
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1. A method for treating an inflammatory disorder in a patient, the method comprising:
evoking a sustained decrease in a level of one or more pro-inflammatory cytokines over an untreated state in the patient without increasing the activity of a humoral anti-inflammatory mediator by directly electrically stimulating the patient'"'"'s vagus nerve from an electrode on the patient'"'"'s vagus nerve, wherein the patient'"'"'s heart rate remains stable for 10 minutes after the vagus nerve is electrically stimulated. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for treating an inflammatory disorder in a patient, the method comprising:
evoking a sustained decrease in a level of tumor necrosis factor (TNF) over an untreated state in the patient without increasing the activity of corticosteroid or IL-I0 by directly electrically stimulating the patient'"'"'s vagus nerve from an electrode on the patient'"'"'s vagus nerve, wherein the patient'"'"'s heart rate remains stable for 10 minutes after the vagus nerve is electrically stimulated. - View Dependent Claims (14, 15, 18)
Specification