METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES

• US 20190202797A1
• Filed: 03/11/2019
• Published: 07/04/2019
• Est. Priority Date: 05/20/2014
• Status: Active Grant

• Current Assignee: Lung Biotechnology PBC (United Therapeutics Corporation)
• Original Assignee: Lung Biotechnology PBC (United Therapeutics Corporation)
• Inventors: Batra, Hitesh, Tuladhar, Sudersan M., Tummala, Sri Harsha, Penmasta, Raju, Walsh, David A.
• Granted Patent: US 10,640,481 B2
• Time in Patent Office: Days
• CPC Class Codes: C07C 233/20 having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
• CPC Class Codes: C07C 2601/10 the ring being unsaturated
• CPC Class Codes: C07C 67/00 Preparation of carboxylic acid esters
• CPC Class Codes: C07C 67/307 by introduction of halogen; by substitution of halogen atoms by other halogen atoms
• CPC Class Codes: C07C 69/65 of unsaturated acids
• CPC Class Codes: C07D 307/93 condensed with a ring other than six-membered
• CPC Class Codes: Y02P 20/55 Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.

Claims

1-7. -7. (canceled)

8. A compound of Formula XV:

9. The compound of claim 8, wherein X is Br, Cl or I.

10. The compound of claim 8, wherein R¹ is methyl or ethyl.

11. The compound of claim 8, having the Formula (XVA)

12. A compound of Formula XVI:

13. A compound of Formula XVII:

14. A method for preparing a compound represented by the structural Formula (II):

15-17. -17. (canceled)