COMBINATION OF PIMAVANSERIN AND CYTOCHROME P450 MODULATORS
First Claim
1. A method of treating psychosis secondary to neurodegenerative disorders in a patient in need thereof, wherein the patient is being treated concurrently with a strong CYP3A4 inhibitor, comprising orally administering to the patient 10 mg of pimavanserin once daily.
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Accused Products
Abstract
A method for treating a disease or disorder in a patient who is currently taking a cytochrome P450 inhibitor comprising administering to the patient a dose of pimavanserin or a pharmaceutical acceptable salt thereof, wherein the dose is at least 20% lower than a dose of pimavanserin or a pharmaceutical acceptable salt thereof that would otherwise have been recommended to the patient if the patient were not currently taking the cytochrome P450 inhibitor.
9 Citations
6 Claims
- 1. A method of treating psychosis secondary to neurodegenerative disorders in a patient in need thereof, wherein the patient is being treated concurrently with a strong CYP3A4 inhibitor, comprising orally administering to the patient 10 mg of pimavanserin once daily.
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5. A method of treating hallucinations and delusions associated with Parkinson'"'"'s disease in a patient in need thereof, wherein the patient is being treated concurrently with ketoconazole, comprising orally administering to the patient 10 mg of pimavanserin once daily.
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6. A method of treating schizophrenia or major depression in a patient in need thereof, comprising orally administering to the patient a unit dose comprising 10 mg pimavanserin once daily, wherein the patient is also being treated with a strong CYP3A4 inhibitor selected from the group consisting of ketoconazole, clarithromycin, indinavir, and itraconazole.
Specification