ANTI-PD-1 ANTIBODIES AND METHODS OF USE THEREOF
First Claim
Patent Images
1. An isolated antibody that specifically binds to human PD-1, comprising a heavy chain variable region comprising complementarity determining regions CDRH1, CDRH2, and CDRH3, wherein CDRH1, CDRH2, and CDRH3 comprise the amino acid sequences of SEQ ID NOs:
- 1, 2, and 7, respectively; and
a light chain variable region comprising the amino acid sequence of SEQ ID NO;
16.
5 Assignments
0 Petitions
Accused Products
Abstract
The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
1 Citation
30 Claims
-
1. An isolated antibody that specifically binds to human PD-1, comprising a heavy chain variable region comprising complementarity determining regions CDRH1, CDRH2, and CDRH3, wherein CDRH1, CDRH2, and CDRH3 comprise the amino acid sequences of SEQ ID NOs:
- 1, 2, and 7, respectively; and
a light chain variable region comprising the amino acid sequence of SEQ ID NO;
16. - View Dependent Claims (2, 3, 4, 24)
- 1, 2, and 7, respectively; and
-
5. An isolated antibody that specifically binds to human PD-1, comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 20; and
a light chain variable region comprising complementarity determining regions CDRL1, CDRL2, and CDRL3, wherein CDRL1, CDRL2, and CDRL3 comprise the amino acid sequences of SEQ ID NOs;
4, 5, and 6, respectively. - View Dependent Claims (6, 25)
- 20; and
-
7. An isolated antibody that specifically binds to human PD-1, comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 17; and
a light chain variable region comprising the amino acid sequence of SEQ ID NO;
16. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 26, 27)
- 17; and
-
16. An isolated antibody that specifically binds to human PD-1, comprising a heavy chain and a light chain, wherein the heavy chain comprises the amino acid sequence of SEQ ID NO:
- 53; and
the light chain comprises the amino acid sequence of SEQ ID NO;
19. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 28, 29, 30)
- 53; and
Specification