ANTI-GALECTIN-9 ANTIBODIES AND USES THEREOF
First Claim
1. A method for inhibiting the activity of galectin-9 or reducing cells expressing galactin-9 in a subject, the method comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an isolated antibody, which binds human galactin-9, wherein the antibody comprises a heavy chain complementarity determining region 1 (CDR1) set forth as SEQ ID NO:
- 361, a heavy chain complementary determining region 2 (CDR2) set forth as SEQ ID NO;
388, and a heavy chain complementary determining region 3 (CDR3) set forth as SEQ ID NO;
406 and/or comprises a light chain complementarity determining region 1 (CDR1) set forth as SEQ ID NO;
328, a light chain complementary determining region 2 (CDR2) set forth as SEQ ID NO;
329, and a light chain complementary determining region 3 (CDR3) set forth as SEQ ID NO;
352.
4 Assignments
0 Petitions
Accused Products
Abstract
Disclosed herein are anti-Galectin-9 antibodies and methods of using such for inhibiting a signaling pathway mediated by Galectin-9 or eliminating pathologic cells expressing Galectin-9. Such anti-Galectin-9 antibodies may also be used to diagnose and/or to treat diseases associated with Galectin-9, such as autoimmune diseases and solid tumors.
2 Citations
20 Claims
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1. A method for inhibiting the activity of galectin-9 or reducing cells expressing galactin-9 in a subject, the method comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an isolated antibody, which binds human galactin-9, wherein the antibody comprises a heavy chain complementarity determining region 1 (CDR1) set forth as SEQ ID NO:
- 361, a heavy chain complementary determining region 2 (CDR2) set forth as SEQ ID NO;
388, and a heavy chain complementary determining region 3 (CDR3) set forth as SEQ ID NO;
406 and/or comprises a light chain complementarity determining region 1 (CDR1) set forth as SEQ ID NO;
328, a light chain complementary determining region 2 (CDR2) set forth as SEQ ID NO;
329, and a light chain complementary determining region 3 (CDR3) set forth as SEQ ID NO;
352. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- 361, a heavy chain complementary determining region 2 (CDR2) set forth as SEQ ID NO;
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11. A method for treating a solid tumor, comprising administering to a human subject in need thereof an effective amount of a pharmaceutical composition comprising an antibody, wherein the antibody comprises a heavy chain complementarity determining region 1 (CDR1) set forth as SEQ ID NO:
- 361, a heavy chain complementary determining region 2 (CDR2) set forth as SEQ ID NO;
388, and a heavy chain complementary determining region 3 (CDR3) set forth as SEQ ID NO;
406 and/or comprises a light chain complementarity determining region 1 (CDR1) set forth as SEQ ID NO;
328, a light chain complementary determining region 2 (CDR2) set forth as SEQ ID NO;
329, and a light chain complementary determining region 3 (CDR3) set forth as SEQ ID NO;
352. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
- 361, a heavy chain complementary determining region 2 (CDR2) set forth as SEQ ID NO;
Specification