Method of Reducing the Likelihood of Skin Cancer in an Individual Human Being
First Claim
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1. A method of reducing the likelihood of skin cancer in an individual human being, said method comprising:
- administering a therapeutically effective amount of a bacterial formulation comprising Nitrosomonas eutropha adapted to produce p53, said bacterial formulation comprising a lotion, ointment or gel adapted to be rubbed onto a region of an individual'"'"'s skin wherein at least some bacteria in the bacterial formulation have been modified by using a using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1(Cpf1) system to remove a virulence factor of the at least some bacteria.
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Abstract
Compositions, systems and methods of improving the health of the microbiome of an individual'"'"'s skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome.
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Citations
20 Claims
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1. A method of reducing the likelihood of skin cancer in an individual human being, said method comprising:
- administering a therapeutically effective amount of a bacterial formulation comprising Nitrosomonas eutropha adapted to produce p53, said bacterial formulation comprising a lotion, ointment or gel adapted to be rubbed onto a region of an individual'"'"'s skin wherein at least some bacteria in the bacterial formulation have been modified by using a using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1(Cpf1) system to remove a virulence factor of the at least some bacteria.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of reducing the likelihood of skin cancer in an individual human being, said method comprising:
- administering a therapeutically effective amount of a bacterial formulation comprising Nitrosomonas eutropha adapted to produce p53, said bacterial formulation including a bifidobacterium strain modified by using a using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1(Cpf1) system to remove a virulence factor.
- View Dependent Claims (13)
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14. A method of reducing the likelihood of skin cancer in an individual human being, said method comprising:
- administering a therapeutically effective amount of a bacterial formulation comprising Nitrosomonas eutropha adapted to produce p53, said bacterial formulation comprising Propionibacterium bacteria, wherein the Propionibacterium bacteria is modified by using a using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1(Cpf1) system to remove a virulence factor.
- View Dependent Claims (15, 16, 17, 18)
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19. A method of reducing the likelihood of skin cancer in an individual human being, said method comprising:
- administering a therapeutically effective amount of a bacterial formulation comprising Nitrosomonas eutropha adapted to produce p53, said bacterial formulation comprising Propionibacterium bacteria, wherein the Propionibacterium bacteria is modified by using a using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1 (Cpf1) system to remove a virulence factor, and administering to the individual human being an immune checkpoint inhibitor.
- View Dependent Claims (20)
Specification