OPHTHALMIC COMPOSITION FOR LOWERING INTRAOCULAR PRESSURE

• US 20190307768A1
• Filed: 06/28/2017
• Published: 10/10/2019
• Est. Priority Date: 11/09/2016
• Status: Active Grant

• Current Assignee: Taejoon Pharmaceutical Co., Ltd.
• Original Assignee: Taejoon Pharmaceutical Co., Ltd.
• Inventors: LEE, Joon Youb, SHIN, Youn Jae, LEE, Min Ji
• Granted Patent: US 10,905,695 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 31/5575 having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 47/44 Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61P 27/02 Ophthalmic agents

Abstract

The present invention relates to an ophthalmic composition for lowering an intraocular pressure, the composition comprising latanoprost, polyoxyl 40 hydrogenated castor oil, and sorbitol.

Claims

1. An ophthalmic composition comprising latanoprost, polyoxyl 40 hydrogenated castor oil (HCO-40) and sorbitol, wherein an amount of the sorbitol is 4.0 to 6.0 w/v % of the total composition.

2. The ophthalmic composition according to claim 1, wherein the amount of the sorbitol is 4.1 to 4.7 w/v % of the total composition.

3. The ophthalmic composition according to claim 1, characterized in that the composition does not comprise a co-gelling agent/co-solubilizing agent.

4. The ophthalmic composition according to claim 1, wherein the amount of the polyoxyl 40 hydrogenated castor oil is 0.3 to 1.0 w/v % of the total composition.

5. The ophthalmic composition according to claim 1, wherein the amount of the polyoxyl 40 hydrogenated castor oil is 0.5 w/v % of the total composition.

6. The ophthalmic composition according to claim 1, wherein the amount of the latanoprost is 0.001 to 0.05 w/v % of the total composition.

7. The ophthalmic composition according to claim 1, wherein the composition may further comprise an active compound.

8. The ophthalmic composition according to claim 1, wherein the composition is a composition for lowering an intraocular pressure.

9. The ophthalmic composition according to claim 8, wherein the composition is used for lowering an intraocular pressure, such that the composition is used in preventing or treating an increased intraocular pressure, ocular hypertension, glaucoma or ophthalmologic diseases related thereto.

10. The ophthalmic composition according to claim 1, wherein the composition is a stabilized composition for lowering an intraocular pressure and the amount of the polvoxyl 40 hydrogenated castor oil is 0.3 to 1.0 w/v % of the total composition.

14. A method for lowering an intraocular pressure, comprising a step of administering the composition of claim 1 into an individual.

15. The ophthalmic composition according to claim 10, wherein the amount of the sorbitol is 4.1 to 4.7 w/v % of the total composition.

16. The ophthalmic composition according to claim 10, wherein the amount of the polyoxyl 40 hydrogenated castor oil is 0.5 w/v % of the total composition.

17. The ophthalmic composition according to claim 10, wherein the amount of the latanoprost is 0.001 to 0.05 w/v % of the total composition.

21. The method according to claim 14, wherein an amount of the polyoxyl 40 hydrogenated castor oil of the composition is 0.3 to 1.0 w/v % of the total composition.

22. The method according to claim 21, wherein an amount of the latanoprost of the composition is 0.001 to 0.05 w/v % of the total composition.

11. (canceled)

12. A method for stabilizing latanoprost, comprising a step of mixing latanoprost, polyoxyl 40 hydrogenated castor oil (HCO-40) and sorbitol, wherein an amount of the polyoxyl 40 hydrogenated castor oil is 0.3 to 1.0 w/v % of the total composition prepared according to the step above.

18. The method according to claim 12, wherein the amount of the sorbitol is 4 to 6 w/v % of the total composition.

19. The method according to claim 12, wherein the amount of the sorbitol is 4.1 to 4.7 w/v % of the total composition.

20. The method according to claim 12, wherein the amount of the latanoprost is 0.001 to 0.05 w/v % of the total composition.

13. (canceled)