METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER AND METABOLIC DISEASES
First Claim
1. A method for treating cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of a retinoid and a histone deacetylase (HDAC) inhibitor.
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Accused Products
Abstract
The invention provides methods and pharmaceutical compositions for treating cancer or a metabolic disease in a subject. In some aspects, the invention comprises administering to the subject a therapeutically effective amount of a retinoid and a histone deacetylase (HDAC) inhibitor. In some embodiments, the HDAC inhibitor is a short-chain fatty acid and/or suberanilohydroxamic acid (SAHA). In other aspects, the invention comprises administering to the subject a therapeutically effective amount of a microRNA. Pharmaceutical compositions and kits for treating a subject with cancer or a metabolic disease are also provided herein.
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74 Claims
- 1. A method for treating cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of a retinoid and a histone deacetylase (HDAC) inhibitor.
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- 27. A method for treating cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of miR-22 or a mimic thereof.
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- 46. A method for treating a metabolic disease in a subject, the method comprising administering to the subject a therapeutically effective amount of a retinoid and a histone deacetylase (HDAC) inhibitor.
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Specification