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PLURIPOTENT STEM CELL THAT INDUCES REPAIR AND REGENERATION AFTER MYOCARDIAL INFARCTION

  • US 20190307806A1
  • Filed: 06/25/2019
  • Published: 10/10/2019
  • Est. Priority Date: 08/17/2012
  • Status: Active Grant
First Claim
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1. A method of treating myocardial infarction in a subject in need thereof, the method comprising:

  • administering to said subject a cell preparation comprising concentrated pluripotent stem cells positive for SSEA-3, wherein the pluripotent stem cells are obtained from a mesenchymal cell population derived from mesenchymal tissue or cultured mesenchymal cells, wherein said pluripotent stem cells have been purified by SSEA-3 positive or concentrated by external stress stimulation, to thereby treat the myocardial infarction, and wherein the pluripotent stem cells have a plurality of properties comprising;

    (i) CD105-positivity;

    (ii) low or absent telomerase activity;

    (iii) ability to differentiate into embryonic endoderm, ectoderm, and mesoderm germ layers;

    (iv) absence of demonstration of neoplastic proliferation; and

    , (v) ability to self-renewal.

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