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COMPOSITIONS

  • US 20190307891A1
  • Filed: 03/27/2019
  • Published: 10/10/2019
  • Est. Priority Date: 09/30/2016
  • Status: Active Grant
First Claim
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1. A composition comprising:

  • (a) an antibody or antibody fragment that binds TNF-alpha, said antibody or said antibody fragment comprising three complementarity determining regions (CDR1-CDR3), wherein CDR1 comprises a sequence sharing 60% or greater sequence identity with SEQ ID NO;

    1, CDR2 comprises a sequence sharing 50% or greater sequence identity with SEQ ID NO;

    2 and CDR3 comprises a sequence sharing 60% or greater sequence identity with SEQ ID NO;

    3; and

    (b) an antibody or antibody fragment that binds IL-6R, said antibody or said antibody fragment comprising three complementarity determining regions (CDR1-CDR3), wherein CDR1 comprises a sequence sharing 60% or greater sequence identity with SEQ ID NO;

    9, CDR2 comprises a sequence sharing 50% or greater sequence identity with SEQ ID NO;

    10 and CDR3 comprises a sequence sharing 60% or greater sequence identity with SEQ ID NO;

    11.

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