PLIABLE SILK MEDICAL DEVICE
First Claim
1. A process for forming a pliable silk fibroin mesh, the process comprising the steps of:
- knitting a first silk fibroin yarn in a first wale direction using the knit pattern 1/1-1/3-3/3-3/1;
knitting a second silk fibroin yarn in a second wale direction using the knit pattern 3/1-1/1-1/3-3/3;
knitting a third silk fibroin yarn in a first course direction using the knit pattern 1/1-5/5-5/5-3/3-3/3-5/5-5/5-3/3-3/3-7/7-7/7-3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5-3/3; and
knitting a fourth silk fibroin yarn in a second course direction using the knit pattern 3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5-1/1-1/1-5/5-5/5-3/3-3/3-5/5-5/5-3/3-3/3-7/7-7/7-3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5,thereby forming the pliable silk fibroin mesh.
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0 Petitions
Accused Products
Abstract
An implantable, pliable silk device (e.g., in a form of a knitted mesh) for use in human soft tissue support and/or repair that provides stretch or pliable properties, e.g., multi-directional elongation properties. Such a device permits physicians or users to alter or manipulate the device dimension and/or shape at the time of device implantation, thereby permitting the device to conform to the contour of a target area or tissue more easily and providing more precise positioning of the device over the target area or tissue. In some embodiments, the implantable pliable silk device comprises a knit pattern feature that substantially prevents unraveling and preserves the stability of the mesh when cut. For example, the pliable silk device is a knitted mesh comprising at least two yarns laid in a knit direction and engaging each other to define a plurality of nodes.
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Citations
30 Claims
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1. A process for forming a pliable silk fibroin mesh, the process comprising the steps of:
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knitting a first silk fibroin yarn in a first wale direction using the knit pattern 1/1-1/3-3/3-3/1; knitting a second silk fibroin yarn in a second wale direction using the knit pattern 3/1-1/1-1/3-3/3; knitting a third silk fibroin yarn in a first course direction using the knit pattern 1/1-5/5-5/5-3/3-3/3-5/5-5/5-3/3-3/3-7/7-7/7-3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5-3/3; and knitting a fourth silk fibroin yarn in a second course direction using the knit pattern 3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5-1/1-1/1-5/5-5/5-3/3-3/3-5/5-5/5-3/3-3/3-7/7-7/7-3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5, thereby forming the pliable silk fibroin mesh. - View Dependent Claims (3, 4, 5, 6)
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2. (canceled)
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7. (canceled)
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8. A pliable silk fibroin mesh formed by a process comprising:
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knitting a first silk fibroin yarn in a first wale direction using the knit pattern 3/1-1/1-1/3-3/3; knitting a second silk fibroin yarn in a second wale direction using the knit pattern 1/1-1/3-3/3-3/1; knitting a third silk fibroin yarn in a first course direction using the knit pattern 3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5-1/1-1/1-5/5-5/5-3/3-3/3-5/5-5/5-3/3-3/3-7/7-7/7-3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5; and knitting a fourth silk fibroin yarn in a second course direction using the knit pattern 1/1-5/5-5/5-3/3-3/3-5/5-5/5-3/3-3/3-7/7-7/7-3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5-3/3-3/3-5/5-5/5-3/3. - View Dependent Claims (9, 10, 11, 12)
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13-23. -23. (canceled)
- 24. An implantable device comprising a knitted network of silk fibroin yarns, wherein the knitted network is characterized in that average elongation at break along a direction of the knitted network formation is greater than 85% and average elongation at break along a width of the knitted network is greater than 85%, and wherein the average pore size of the knitted network is greater than 1 mm2.
Specification