PACING MODE SWITCHING AND RATE RESPONSE LIMIT IN A VENTRICULAR PACEMAKER

• US 20190308022A1
• Filed: 04/09/2018
• Published: 10/10/2019
• Est. Priority Date: 04/09/2018
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: DEMMER, Wade M., PRONOVICI, Juliana E., SHELDON, Todd J.
• Granted Patent: US 11,185,701 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/02444 Details of sensor A61B5/02427 takes precedence
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/1107 Measuring contraction of parts of the body, e.g. organ, muscle apparatus for measuring work or force in general G01L
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61N 1/025 Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
• CPC Class Codes: A61N 1/0573 chacterised by means penetrating the heart tissue, e.g. helix needle or hook
• CPC Class Codes: A61N 1/36507 controlled by gradient or slope of the heart potential
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/36592 controlled by the heart rate variability
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3688 configured for switching the pacing mode, e.g. from AAI to DDD
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators
• CPC Class Codes: A61N 1/37288 : Communication to several implantable medical devices within one patient
• CPC Class Codes: A61N 1/3756 : Casings with electrodes thereon, e.g. leadless stimulators

Abstract

An intracardiac ventricular pacemaker having a motion sensor, a pulse generator and a control circuit coupled to the pulse generator and the motion sensor is configured to identify a ventricular systolic event, detect a ventricular passive filling event signal from the motion signal, and determine a time interval from the ventricular systolic event to the ventricular passive filling event. The pacemaker establishes a minimum pacing interval based on the time interval.

Claims

1. An intracardiac ventricular pacemaker, comprising:

a pulse generator configured to generate and deliver pacing pulses to a ventricle of a patient'"'"'s heart via electrodes coupled to the pacemaker;

a motion sensor configured to produce a motion signal;

a control circuit coupled to the motion sensor and the pulse generator; and

a housing wholly implantable within a ventricular chamber of the patient'"'"'s heart and enclosing the pulse generator, the motion sensor and the control circuit;

the control circuit being configured to;

identify a ventricular systolic event;

detect a ventricular passive filling event signal from the motion signal;

determine a time interval from the ventricular systolic event to the ventricular passive filling event;

establish a minimum pacing interval based on the time interval;

determine a sensor indicated pacing rate interval;

compare the sensor indicated pacing rate interval to the minimum pacing interval; and

control the pulse generator to deliver a ventricular pacing pulse at the minimum pacing interval in response to the sensor indicated pacing rate interval being less than the minimum pacing interval.

2. The pacemaker of claim 1, wherein the control circuit is configured to:

control the pulse generator to deliver ventricular pacing pulses in an atrial tracking pacing mode by;

detecting an atrial systolic event from the motion signal,

setting an atrioventricular pacing interval in response to detecting the atrial systolic event, and

controlling the pulse generator to deliver a ventricular pacing pulse upon expiration of the atrioventricular pacing interval; and

determine the time interval during the atrial tracking pacing mode.

3. The pacemaker of claim 2, wherein the control circuit is further configured to:

determine that pacing mode switching criteria are satisfied;

switch from controlling the pulse generator in the atrial tracking pacing mode to controlling the pulse generator in a non-atrial tracking pacing mode in response to the pacing mode switching criteria being satisfied; and

determine the sensor indicated rate during the non-atrial tracking pacing mode.

4. The pacemaker of claim 2, wherein the control circuit is further configured to:

set an atrial refractory period in response to identifying the ventricular systolic event;

detect the ventricular passive filling event from the motion signal during the atrial refractory period; and

detect the atrial systolic event outside the atrial refractory period.

5. The pacemaker of claim 1, wherein the control circuit is configured to:

detect a resting stable heart rate; and

determine the time interval during the resting stable heart rate.

6. The pacemaker of claim 1, wherein the control circuit is configured to:

determine the time interval for a plurality of heart rates;

extrapolate a corrected time interval for a heart rate greater than the plurality of heart rates; and

establish the minimum pacing rate interval based on the corrected time interval.

7. The pacemaker of claim 1, wherein the control circuit is further configured to:

determine a corrected time interval based on a function of the time interval and a target heart rate interval; and

establish the minimum pacing rate interval based on the corrected time interval.

8. The pacemaker of claim 1, wherein the control circuit is configured to identify the ventricular systolic event from the motion signal.

9. The pacemaker of claim 1, further comprising a sensing circuit configured to receive a cardiac electrical signal and sense an R-wave from the cardiac electrical signal,

wherein the control circuit is configured to identify the ventricular systolic event as one of a ventricular pacing pulse or the sensed R-wave.

10. The pacemaker of claim 1, wherein the control circuit is further configured to:

determine an ensemble averaged motion signal from the motion signal acquired over a plurality of cardiac cycles; and

determine the time interval from the ensemble averaged motion signal.

11. The pacemaker of claim 1, wherein the control circuit is configured to:

control the pulse generator to deliver ventricular pacing pulses in an atrial tracking pacing mode by;

determining an ensemble averaged motion signal from the motion signal acquired over a plurality of cardiac cycles;

determining the time interval from the ensemble averaged motion signal;

setting an atrial refractory period based on the time interval;

detecting an atrial systolic event from the motion signal outside the atrial refractory period;

setting an atrioventricular pacing interval in response to detecting the atrial systolic event;

controlling the pulse generator to deliver a ventricular pacing pulse upon expiration of the atrioventricular pacing interval;

determining a metric from the motion signal correlated to a reliability of atrial systolic event detection; and

switching from the atrial tracking pacing mode to a non-atrial tracking pacing mode in response to the metric satisfying pacing mode switching criteria; and

controlling the pulse generator to deliver ventricular pacing pulses in the non-atrial tracking pacing mode by controlling pulse generator to deliver a ventricular pacing pulse at the sensor indicated pacing rate interval in response to the sensor indicated pacing rate interval being equal to or greater than the minimum pacing interval.

12. The pacemaker of claim 1, wherein to determine the sensor indicated pacing rate interval, the control circuit is configured to determine the sensor indicated pacing rate based on the motion signal.

13. A method performed by an intracardiac ventricular pacemaker having a motion sensor configured to produce a motion signal, the method comprising:

identifying a ventricular systolic event by a control circuit of the pacemaker;

detecting by the control circuit a ventricular passive filling event signal from the motion signal produced by the motion sensor within a ventricular chamber of the patient'"'"'s heart;

determining a time interval from the ventricular systolic event to the ventricular passive filling event;

establishing a minimum pacing interval based on the time interval;

determining a sensor indicated pacing rate interval;

comparing the sensor indicated pacing rate interval to the minimum pacing interval; and

controlling a pulse generator to deliver a ventricular pacing pulse at the minimum pacing interval in response to the sensor indicated pacing rate interval being less than the minimum pacing interval.

14. The method of claim 13, further comprising:

controlling the pulse generator to deliver ventricular pacing pulses in an atrial tracking pacing mode by;

detecting an atrial systolic event from the motion signal,

setting an atrioventricular pacing interval in response to detecting the atrial systolic event, and

controlling the pulse generator to deliver a ventricular pacing pulse upon expiration of the atrioventricular pacing interval; and

determining the time interval during the atrial tracking pacing mode.

15. The method of claim 14, further comprising:

determining by the control circuit that pacing mode switching criteria are satisfied;

switching from controlling the pulse generator in the atrial tracking pacing mode to controlling the pulse generator in a non-atrial tracking pacing mode in response to the pacing mode switching criteria being satisfied; and

determining the sensor indicated rate during the non-atrial tracking pacing mode.

16. The method of claim 15, further comprising:

setting an atrial refractory period in response to identifying the ventricular systolic event;

detecting the ventricular passive filling event from the motion signal during the atrial refractory period; and

detecting the atrial systolic event outside the atrial refractory period.

17. The method of claim 13, further comprising:

detecting a resting stable heart rate; and

determining the time interval during the resting stable heart rate.

18. The method of claim 13, further comprising:

determining the time interval for a plurality of heart rates;

extrapolating a corrected time interval for a heart rate greater than the plurality of heart rates; and

establishing the minimum pacing rate interval based on the corrected time interval.

19. The method of claim 13, further comprising:

determining a corrected time interval based on a function of the time interval and a target heart rate interval; and

establishing the minimum pacing rate interval based on the corrected time interval.

20. The method of claim 13, further comprising identifying the ventricular systolic event from the motion signal.

21. The method of claim 13, further comprising:

sensing an R-wave from a cardiac electrical signal received by a sensing circuit configured of the pacemaker,

wherein identifying the ventricular systolic event comprises identifying one of a ventricular pacing pulse and the sensed R-wave.

22. The method of claim 13, further comprising:

determining an ensemble averaged motion signal from the motion signal acquired over a plurality of cardiac cycles; and

determining the time interval from the ensemble averaged motion signal.

23. The method of claim 13, further comprising:

controlling the pulse generator to deliver ventricular pacing pulses in an atrial tracking pacing mode by;

determining an ensemble averaged motion signal from the motion signal acquired over a plurality of cardiac cycles;

determining the time interval from the ensemble averaged motion signal;

setting an atrial refractory period based on the time interval;

detecting an atrial systolic event from the motion signal outside the atrial refractory period;

setting an atrioventricular pacing interval in response to detecting the atrial systolic event;

controlling the pulse generator to deliver a ventricular pacing pulse upon expiration of the atrioventricular pacing interval;

determining a metric from the motion signal correlated to a reliability of atrial systolic event detection; and

switching from the atrial tracking pacing mode to a non-atrial tracking pacing mode in response to the metric satisfying pacing mode switching criteria; and

controlling the pulse generator to deliver ventricular pacing pulses in the non-atrial tracking pacing mode by controlling pulse generator to deliver a ventricular pacing pulse at the sensor indicated pacing rate interval in response to the sensor indicated pacing rate interval being equal to or greater than the minimum pacing interval.

24. The method of claim 13, wherein determining the sensor indicated pacing rate interval comprises determining the sensor indicated pacing rate interval based on the motion signal.

25. A non-transitory, computer-readable medium storing a set of instructions, which, when executed by a control circuit of an intracardiac ventricular pacemaker having a motion sensor configured to produce a motion signal, cause the pacemaker to:

identify a ventricular systolic event;

detect a ventricular passive filling event signal from the motion signal produced by the motion sensor within a ventricular chamber of a patient'"'"'s heart;

determine a time interval from the ventricular systolic event to the ventricular passive filling event;

establish a minimum pacing interval based on the time interval;

determine a sensor indicated pacing rate interval;

compare the sensor indicated pacing rate interval to the minimum pacing interval; and

deliver a ventricular pacing pulse at the minimum pacing interval in response to the sensor indicated pacing rate interval being less than the minimum pacing interval.