QUINOXALINE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS
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Abstract
A compound, capable of inhibiting kinases, for the treatments of diseases or disorders mediated by such kinases, has a structure of formula (I):
or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof. The compound can be used in the treatments of diseases or conditions mediated by CSF-1R, c-KIT, FLT3, or PDGFR kinases. Such diseases or conditions may include cancers, autoimmune diseases, and bone resorptive diseases.
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Citations
20 Claims
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1. A compound of formula (I):
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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2. The compound of claim 1, wherein G is selected from:
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3. The compound of claim 1, wherein G is selected from:
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4. The compound of claim 1, wherein G is selected from:
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5. The compound of claim 1, wherein G is selected from:
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6. The compound of claim 1, wherein G is:
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7. The compound of claim 1, wherein X is NH.
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8. The compound of claim 1, wherein Z is —
- O—
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- O—
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9. The compound of claim 1, where the compound is:
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3-methoxy-6-((6-(((6-(trifluoromethyl)pyridin-3-yl)methyl)amino)pyridin-3-yl)amino)quinoxaline-5-carbonitrile; N5-(3-methoxyquinoxalin-6-yl)-N2-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridine-2,5-diamine; 3-methoxy-6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino)quinoxaline-5-carbonitrile; 3-methoxy-6-((6-((4-(trifluoromethyl)benzyl)amino)pyridin-3-yl)amino)quinoxaline-5-carbonitrile; 3-methoxy-N-(3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)quinoxalin-6-amine; 3-methoxy-6-((6-(pyridin-3-ylmethoxy)pyridin-3-yl)amino)quinoxaline-5-carbonitrile; 3-(dimethylamino)-6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino)quinoxaline-5-carbonitrile; 3-methoxy-6-((3-methoxy-4-(pyridin-3-ylmethoxy)phenyl)amino)quinoxaline-5-carbonitrile; 3-methoxy-6-((6-((4-methoxybenzyl)oxy)pyridin-3-yl)amino)quinoxaline-5-carbonitrile; 3-methoxy-6-(3-methoxy-4-((4-methoxybenzyl)oxy)phenoxy)quinoxaline-5-carbonitrile; 6-(3-methoxy-4-(4-methoxybenzyloxy)phenylamino)-3-(methylamino)quinoxaline-5-carbonitrile; 3-(2-(dimethylamino)ethoxy)-6-(3-methoxy-4-(4-methoxybenzyloxy)phenylamino)-quinoxaline-5-carbonitrile; 3-methoxy-6-(3-methoxy-4-(4-methoxybenzylamino)phenylamino)quinoxaline-5-carbonitrile; 3-methoxy-6-(4-(4-methoxybenzyloxy)phenylamino)quinoxaline-5-carbonitrile; 6-(3-methoxy-4-(4-methoxybenzyloxy)phenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 3-(isopropylamino)-6-(3-methoxy-4-(4-methoxybenzyloxy)phenylamino)quinoxaline-5-carbonitrile; 6-(2-fluoro-4-(4-methoxybenzyloxy)phenylamino)-3-methoxyquinoxaline-5-carbonitrile; 3-(dimethylamino)-6-(3-methoxy-4-(4-methoxybenzyloxy)phenoxy)quinoxaline-5-carbonitrile; 6-(4-(4-ethoxybenzyloxy)-3-methoxyphenylamino)-3-methoxyquinoxaline-5-carbonitrile; 3-methoxy-6-(3-methoxy-4-(4-(trifluoromethoxy)benzyloxy)phenylamino)quinoxaline-5-carbonitrile; 6-(3-fluoro-4-(4-methoxybenzyloxy)phenylamino)-3-methoxyquinoxaline-5-carbonitrile; 6-(4-(benzyloxy)-3-methoxyphenylamino)-3-methoxyquinoxaline-5-carbonitrile; N-(3-methoxy-4-(4-methoxybenzyloxy)phenyl)-3-morpholinoquinoxalin-6-amine; N7-(3-methoxy-4-(4-methoxybenzyloxy)phenyl)-N2-methylquinoxaline-2,7-diamine; 3-methoxy-6-(3-methoxy-4-(4-methoxybenzyloxy)phenoxy)quinoxaline-5-carbonitrile; 6-(3-methoxy-4-(4-methoxybenzyloxy)phenoxy)-3-morpholinoquinoxaline-5-carbonitrile; 6-(4-(4-chlorobenzyloxy)-3-methoxyphenoxy)-3-methoxyquinoxaline-5-carbonitrile; 6-(4-(4-isopropylbenzylamino)-3-methoxyphenylamino)-3-methoxyquinoxaline-5-carbonitrile; 6-(3-ethoxy-4-(4-methoxybenzyloxy)phenoxy)-3-methoxyquinoxaline-5-carbonitrile; 6-(3-methoxy-4-(4-methoxybenzyloxy)phenylamino)-3-(4-methylpiperazin-1-yl) quinoxaline-5-carbonitrile 6-(3-methoxy-4-(4-(trifluoromethoxy)benzyloxy)phenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(4-(4-ethylbenzyloxy)-3-methoxyphenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(4-(4-fluorobenzyloxy)-3-methoxyphenylamino)-3-methoxyquinoxaline-5-carbonitrile; 6-(4-(4-ethoxybenzyloxy)-3-methoxyphenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(4-(cyclopropylmethoxy)-3-methoxyphenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(5-methoxy-6-(4-methoxybenzyloxy)pyridin-3-ylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(4-(4-methoxybenzyloxy)phenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(3-methoxy-4-(4-methoxybenzylamino)phenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(4-(4-fluorobenzyloxy)-3-methoxyphenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(3-methoxy-4-((3-methyloxetan-3-yl)methoxy)phenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(3-methoxy-4-((1-methylpiperidin-4-yl)methoxy)phenylamino)-3-morpholino-quinoxaline-5-carbonitrile; 6-(3-methoxy-4-(pyridin-3-ylmethoxy)phenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(4-(cyclopentylmethoxy)-3-methoxyphenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(4-((2,3-dihydrobenzofuran-5-yl)methoxy)-3-methoxyphenylamino)-3-morpholino-quinoxaline-5-carbonitrile; 6-(3-methoxy-4-(pyridin-4-ylmethoxy)phenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(3-ethoxy-4-(pyridin-4-ylmethoxy)phenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(3-methoxy-4-((1-methyl-1H-imidazol-2-yl)methoxy)phenylamino)-3-morpholino-quinoxaline-5-carbonitrile; 6-(4-(4-chlorobenzyloxy)-3-methoxyphenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenylamino)-3-morpholino-quinoxaline-5-carbonitrile; 6-(3-methoxy-4-(pyrazin-2-ylmethoxy)phenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(6-(4-methoxybenzyloxy)pyridin-3-ylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(2-fluoro-4-(4-methoxybenzyloxy)phenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(3-methoxy-4-((6-methylpyridin-3-yl)methoxy)phenylamino)-3-morpholino-quinoxaline-5-carbonitrile; 6-(3-methoxy-4-((1-methyl-1H-imidazol-5-yl)methoxy)phenylamino)-3-morpholino-quinoxaline-5-carbonitrile; 6-(3-fluoro-4-(4-methoxybenzyloxy)phenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(3-methoxy-4-(pyridin-2-ylmethoxy)phenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(4-(3,4-dimethoxybenzyloxy)-3-methoxyphenylamino)-3-morpholinoquinoxaline-5-carbonitrile; 6-(3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenylamino)-3-(piperazin-1-yl) quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)(methyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((5-methylisoxazol-3-yl)methoxy)phenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino)-3-(pyrrolidin-1-yl)quinoxaline-5-carbonitrile; 6-((3-chloro-4-((4-methoxybenzyl)oxy)phenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((4-((4-cyanobenzyl)oxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((4-((3-cyanobenzyl)oxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 3-(4-(2-hydroxyethyl)piperazin-1-yl)-6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl) amino)quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((6-methylpyridin-3-yl)methoxy)phenyl)amino)-3-(piperazin-1-yl) quinoxaline-5-carbonitrile; 1-(8-cyano-7-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino)quinoxalin-2-yl) piperidin-4-yl acetate; 6-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)amino)-3-(4-methylpiperidin-1-yl)quinoxaline-5-carbonitrile; 3-(1H-imidazol-1-yl)-6-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)amino)quinoxaline-5-carbonitrile; (1-(8-cyano-7-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino)quinoxalin-2-yl) piperidin-4-yl)methyl acetate; 3-(4-acetylpiperazin-1-yl)-6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino) quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((6-(trifluoromethyl)pyridin-3-yl)methoxy)phenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 2-(4-(8-cyano-7-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)amino) quinoxalin-2-yl)piperazin-1-yl)ethyl acetate; 3-(4-(2-hydroxyethyl)piperazin-1-yl)-6-((3-methoxy-4-((6-methoxypyridin-3-yl) methoxy)phenyl)amino)quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino)-3-((2-morpholinoethyl)amino) quinoxaline-5-carbonitrile; 3-((1-benzylpiperidin-4-yl)amino)-6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl) amino)quinoxaline-5-carbonitrile; 6-((4-((3-cyanobenzyl)oxy)-3-methoxyphenyl)amino)-3-(4-methylpiperazin-1-yl) quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)amino)-3-(pyrrolidin-1-yl) quinoxaline-5-carbonitrile; 3-(4-isopropylpiperazin-1-yl)-6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino) quinoxaline-5-carbonitrile; 6-((4-(benzo[d][1,3]dioxol-5-ylmethoxy)-3-methoxyphenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 3-(4-(dimethylamino)piperidin-1-yl)-6-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)amino)quinoxaline-5-carbonitrile; 3-(azetidin-1-yl)-6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino)quinoxaline-5-carbonitrile; 6-((4-((3-cyanobenzyl)oxy)-3-methoxyphenyl)amino)-3-(4-(dimethylamino) piperidin-1-yl)quinoxaline-5-carbonitrile; 3-(4-(dimethylamino)piperidin-1-yl)-6-((4-((3-fluoro-4-methoxybenzyl)oxy)-3-methoxyphenyl)amino)quinoxaline-5-carbonitrile; 3-(azetidin-1-yl)-6-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)amino) quinoxaline-5-carbonitrile; 3-(azetidin-1-yl)-6-((4-((3-cyanobenzyl)oxy)-3-methoxyphenyl)amino)quinoxaline-5-carbonitrile; 6-((4-(benzyloxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 3-(4-(dimethylamino)piperidin-1-yl)-6-((4-((3-fluorobenzyl)oxy)-3-methoxyphenyl) amino)quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino)-3-(piperazin-1-yl)quinoxaline-5-carbonitrile; 6-((4-((3-fluorobenzyl)oxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((4-((3-fluoro-4-methoxybenzyl)oxy)-3-methoxyphenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((4-((2-fluoro-4-methoxybenzyl)oxy)-3-methoxyphenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)amino)-3-(4-methyl-piperazin-1-yl)quinoxaline-5-carbonitrile; 6-((4-((3-cyano-4-methoxybenzyl)oxy)-3-methoxyphenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)amino)-3-(4-(2-methoxyethyl)piperazin-1-yl)quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((6-propylpyridin-3-yl)methoxy)phenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((4-((3,4-difluorobenzyl)oxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((3-methoxy-4-((6-methylpyridin-3-yl)methoxy)phenyl)amino)-3-(4-(2-methoxyethyl) piperazin-1-yl)quinoxaline-5-carbonitrile; 6-((4-((6-ethylpyridin-3-yl)methoxy)-3-methoxyphenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)amino)-3-(4-morpholino-piperidin-1-yl)quinoxaline-5-carbonitrile; 6-((4-((6-isopropylpyridin-3-yl)methoxy)-3-methoxyphenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((4-((6-(dimethylamino)pyridin-3-yl)methoxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((3-methoxy-4-((1-methyl-1H-pyrazol-4-yl)methoxy)phenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; N-(3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)-3-(prop-1-en-2-yl)quinoxalin-6-amine; 6-((3-methoxy-4-((6-(methoxymethyl)pyridin-3-yl)methoxy)phenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino)-3-(prop-1-en-2-yl) quinoxaline-5-carbonitrile; 3-isopropyl-6-((3-methoxy-4-((4-methoxybenzyl)oxy)phenyl)amino)quinoxaline-5-carbonitrile; 6-((4-((6-(fluoromethyl)pyridin-3-yl)methoxy)-3-methoxyphenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((4-((6-(difluoromethyl)pyridin-3-yl)methoxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((4-((6-ethoxypyridin-3-yl)methoxy)-3-methoxyphenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 3-(3,6-dihydro-2H-pyran-4-yl)-6-((3-methoxy-4-((6-methylpyridin-3-yl)methoxy)phenyl)amino)quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((6-methylpyridin-3-yl)methoxy)phenyl)amino)-3-(tetrahydro-2H-pyran-4-yl)quinoxaline-5-carbonitrile; 6-((4-((6-((dimethylamino)methyl)pyridin-3-yl)methoxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((3-methoxy-4-((1-ethyl-1H-pyrazol-4-yl)methoxy)phenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((1-propyl-1H-pyrazol-4-yl)methoxy)phenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 3-(4-cyclopropylpiperazin-1-yl)-6-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy) phenyl)amino)quinoxaline-5-carbonitrile; 3-isopropoxy-6-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)amino) quinoxaline-5-carbonitrile; 6-((4-((6-cyclopropylpyridin-3-yl)methoxy)-3-methoxyphenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((4-(furan-3-ylmethoxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((4-(furan-2-ylmethoxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((3-methoxy-4-((tetrahydrofuran-2-yl)methoxy)phenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((5-methylthiophen-2-yl)methoxy)phenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((5-(methoxymethyl)pyridin-2-yl)methoxy)phenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((3-methoxy-4-(thiophen-3-ylmethoxy)phenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((3-methoxy-4-(thiophen-2-ylmethoxy)phenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((3-methoxy-4-((2-methylpyrimidin-5-yl)methoxy)phenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((3-methoxy-4-((6-methylpyridin-3-yl)methoxy)phenyl)(methyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 6-((4-((6-cyclopropylpyridin-3-yl)methoxy)-3-methoxyphenyl)(methyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((4-((1-(2-fluoroethyl)-1H-pyrazol-4-yl)methoxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((3-methoxy-4-((5-methoxypyridin-2-yl)methoxy)phenyl)amino)-3-morpholino-quinoxaline-5-carbonitrile; 3-(dimethylamino)-6-((3-methoxy-4-((6-methylpyridin-3-yl)methoxy)phenyl)amino) quinoxaline-5-carbonitrile; 6-((4-((1-cyclopropyl-1H-pyrazol-4-yl)methoxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((3-methoxy-4-((6-methylpyridin-3-yl)methoxy)phenyl)amino)-3-morpholinoquinoxaline-5-carboxamide; 3-(3-(dimethylamino)azetidin-1-yl)-6-((3-methoxy-4-((6-methylpyridin-3-yl)methoxy) phenyl)amino)quinoxaline-5-carbonitrile; 3-(dimethylamino)-6-((3-methoxy-4-((6-methoxypyridin-3-yl)methoxy)phenyl)amino) quinoxaline-5-carbonitrile; 3-(3-methoxy-3-methylazetidin-1-yl)-6-((3-methoxy-4-((6-methylpyridin-3-yl)methoxy) phenyl)amino)quinoxaline-5-carbonitrile; 6-((4-((3-cyano-4-methoxybenzyl)oxy)-3-methoxyphenyl)amino)-3-(dimethylamino) quinoxaline-5-carbonitrile; 6-((4-((3-cyano-4-methoxybenzyl)oxy)-3-methoxyphenyl)amino)-3-methoxyquinoxaline-5-carbonitrile; 6-((4-((1-(cyclopropylmethyl)-1H-pyrazol-4-yl)methoxy)-3-methoxyphenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 3-morpholino-6-((6-((4-(trifluoromethyl)benzyl)amino)pyridin-3-yl)amino)quinoxaline-5-carbonitrile; 6-((5-methoxy-6-((6-methylpyridin-3-yl)methoxy)pyridin-3-yl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 6-((5-methoxy-6-((6-methoxypyridin-3-yl)methoxy)pyridin-3-yl)amino)-3-morpholinoquinoxaline-5-carbonitrile; 3-((2S,6R)-2,6-dimethylmorpholino)-6-((3-methoxy-4-((6-methylpyridin-3-yl)methoxy) phenyl)amino)quinoxaline-5-carbonitrile;
or6-((3-methoxy-4-((6-methyl-1-(λ
1-oxidaneyl)-1λ
4-pyridin-3-yl)methoxy)phenyl)amino)-3-morpholinoquinoxaline-5-carbonitrile.
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10. A pharmaceutical composition comprising the compound according to claim 1, a stereoisomer thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable diluent or carrier.
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11. The pharmaceutical composition of claim 10 for use in treating a disease or disorder mediated by CSF-1R, FLT3, c-KIT, and/or PDGFR kinase, or mediated by a mutant kinase of CSF-1R, FLT3, c-KIT, or PDGFR.
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12. A method for treating a disease or disorder mediated by CSF-1R, FLT3, c-KIT, and/or PDGFR kinase, comprising administering to a subject in need thereof a therapeutically effective amount of the pharmaceutical composition of claim 10.
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13. The method according to claim 12, wherein the disease or disorder is a cancer.
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14. The method according to claim 13, wherein the cancer is selected from the group consisting of multiple myeloma, acute myeloid leukemia (AML), chronic myeloid leukemia (CML), prostate cancer, breast cancer, ovarian cancer, melanoma, glioblastoma multiforme, giant cell tumor of bone, non-small-cell lung cancers, giant cell tumor of the tendon sheath, metastasis of tumors to other tissues, myelofibrosis, pigmented villonodular synovitis, and gastrointestinal stromal tumor.
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15. The compound of claim 2, wherein X is NH.
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16. The compound of claim 3, wherein X is NH.
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17. The compound of claim 4, wherein X is NH.
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18. The compound of claim 5, wherein X is NH.
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19. The compound of claim 6, wherein X is NH.
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20. The compound of claim 2, wherein Z is —
- O—
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- O—
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2. The compound of claim 1, wherein G is selected from:
Specification
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Current AssigneeDevelopment Center for Biotechnology
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Original AssigneeDevelopment Center for Biotechnology
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InventorsPeng, Shao-Zheng, Liao, Chu-Bin, Chen, Hung-Kai, Ho, Chen-Hsuan, Huang, Hung-Jyun, Chiou, Shian-Yi
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Granted Patent
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Time in Patent OfficeDays
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Field of Search
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US Class Current
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CPC Class CodesA61P 19/02 for joint disorders, e.g. a...A61P 19/08 for bone diseases, e.g. rac...A61P 35/00 Antineoplastic agentsA61P 35/02 specific for leukemiaA61P 35/04 specific for metastasisA61P 43/00 Drugs for specific purposes...C07D 241/44 with hetero atoms or with c...C07D 241/52 Oxygen atomsC07D 401/04 directly linked by a ring-m...C07D 401/12 linked by a chain containin...C07D 401/14 containing three or more he...C07D 403/04 directly linked by a ring-m...C07D 403/12 linked by a chain containin...C07D 403/14 containing three or more he...C07D 405/12 linked by a chain containin...C07D 409/12 linked by a chain containin...C07D 413/04 directly linked by a ring-m...C07D 413/12 linked by a chain containin...C07D 413/14 containing three or more he...