HETEROCYCLIC COMPOUNDS AND USES THEREOF

• US 20190308963A1
• Filed: 04/04/2019
• Published: 10/10/2019
• Est. Priority Date: 04/07/2018
• Status: Active Grant

• Current Assignee: Fuqiang Ruan
• Original Assignee: Fuqiang Ruan
• Inventors: Ruan, Fuqiang
• Granted Patent: US 10,442,799 B1
• Time in Patent Office: Days
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 413/14 containing three or more hetero rings
• CPC Class Codes: C07D 471/04 Ortho-condensed systems
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

In recognition of the unmet need to develop novel therapeutic agents, the present invention discloses a novel class of heterocycles as dual inhibitors of BRD4 and class I PI3Ks. The compounds claimed herein could be used alone or in combination therapies for the effective treatment of a wide range of age-related diseases, including cancer. The present invention also provides methods for preparing compounds of the invention thereto.

Claims

1. A compound having the structure:

3. A compound of claims 1 and 2 or a pharmaceutically acceptable salt thereof, wherein the compound includes:

2. A compound having the structure: