ANTIGEN BINDING CONSTRUCTS TO CD3

• US 20190309068A1
• Filed: 04/25/2019
• Published: 10/10/2019
• Est. Priority Date: 06/15/2012
• Status: Active Grant

• Current Assignee: ImaginAb, Inc.
• Original Assignee: ImaginAb, Inc.
• Inventors: Ho, David T., Olafsen, Tove, Romero, Jason, Behrenbruch, Christian P.
• Granted Patent: US 10,882,909 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 47/6849 the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
• CPC Class Codes: A61K 51/1027 against receptors, cell-surface antigens or cell-surface determinants
• CPC Class Codes: C07K 16/2809 against the T-cell receptor (TcR)-CD3 complex
• CPC Class Codes: C07K 2317/24 containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
• CPC Class Codes: C07K 2317/526 CH3 domain
• CPC Class Codes: C07K 2317/53 Hinge
• CPC Class Codes: C07K 2317/565 Complementarity determining region [CDR]
• CPC Class Codes: C07K 2317/622 Single chain antibody (scFv)
• CPC Class Codes: C07K 2317/626 Diabody or triabody
• CPC Class Codes: C07K 2317/64 comprising a combination of variable region and constant region components
• CPC Class Codes: G01N 2333/7051 T-cell receptor (TcR)-CD3 complex
• CPC Class Codes: G01N 33/56966 Animal cells

Abstract

Antigen binding constructs that bind to CD3, for example antibodies, including antibody fragments (such as minibodies and cys-diabodies) that bind to CD3, are described herein. Methods of use are described herein.

Claims

1. A polypeptide having the amino acid sequence of SEQ ID NO:

9.