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CELL ENGAGING BINDING MOLECULES

  • US 20190309094A1
  • Filed: 04/01/2019
  • Published: 10/10/2019
  • Est. Priority Date: 04/10/2018
  • Status: Active Grant
First Claim
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1. A binding molecule, comprising:

  • (a) a first polypeptide and a second polypeptide, each comprising an antibody light chain,(b) a third polypeptide comprising, in the order from N-terminus to C-terminus, a first variable heavy (VH) region and a first constant heavy 1 (CH1) region, and a second VH region; and

    (c) a fourth polypeptide comprising, in the order from N-terminus to C-terminus, a third VH region and a second CH1 region, and a variable light (VL) region,wherein the first polypeptide and the first VH region and the first CH1 region of the third polypeptide form a first antigen binding Fab region;

    wherein the second polypeptide and the third VH region and the second CH1 region of the fourth polypeptide form a second antigen binding Fab region;

    wherein the second VH region of the third polypeptide and the VL region of the fourth polypeptide form an antigen binding Fv region; and

    wherein the first Fab region and the second Fab region each binds to CD20 or epidermal growth factor receptor (EGFR), and the Fv region binds to CD3.

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