ANTIBODY-DRUG CONJUGATE HAVING CYCLIC BENZYLIDENE ACETAL LINKER
First Claim
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1. A compound having a cyclic benzylidene acetal linker represented by formula (3) or formula (4):
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Abstract
An antibody-drug conjugate having a cyclic benzylidene acetal linker represented by formula (1) or formula (2), wherein Y is an antibody; D is a drug; R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 20; and Z1 and Z2 are each independently a selected divalent spacer:
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8 Claims
- 1. A compound having a cyclic benzylidene acetal linker represented by formula (3) or formula (4):
- 4. A compound having a cyclic benzylidene acetal linker represented by formula (5) or formula (6):
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