PRODUCTION OF FRAMBINONE BY A RECOMBINANT FUNGAL MICROORGANISM
First Claim
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1. A genetically modified fungal microorganism for the production of frambinone, said microorganism having the following characteristics:
- a capacity to produce frambinone from tyrosine; and
a limited capacity or no capacity to break tyrosine down into tyrosol, p-hydroxyphenylacetaldehyde and/or p-hydroxyphenylacetate.
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Abstract
The invention relates to a genetically modified fungal microorganism for the production of frambinone, said microorganism having the following characteristics: —the capacity to produce frambinone from tyrosine; and —a limited capacity or no capacity to break tyrosine down into tyrosol, p-hydroxyphenylacetaldehyde and/or p-hydroxyphenylacetate; and to the use of same for producing frambinone.
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19 Claims
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1. A genetically modified fungal microorganism for the production of frambinone, said microorganism having the following characteristics:
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a capacity to produce frambinone from tyrosine; and a limited capacity or no capacity to break tyrosine down into tyrosol, p-hydroxyphenylacetaldehyde and/or p-hydroxyphenylacetate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 10, 16, 17, 18, 19)
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9. (canceled)
- 11. A process for the production of frambinone comprising culturing a fungal microorganism with a capacity to produce frambinone from tyrosine in a medium comprising tyrosine and a repressor of the path for breaking tyrosine down into tyrosol, p-hydroxyphenylacetaldehyde and/or p-hydroxyphenylacetate.
Specification