ENHANCED INTERFERENCE MEMBRANE FOR A WORKING ELECTRODE OF A CONTINUOUS BIOLOGICAL SENSOR
First Claim
1. A subcutaneous sensor for use with a continuous metabolic monitor for a patient, comprising:
- a working electrode further comprising;
a conductive substrate;
an enzyme membrane comprising an enzyme selected for a target metabolic function;
an interference membrane between the conductive substrate and the enzyme membrane, the interference membrane being conformally deposited on the substrate surface; and
a glucose limiting layer applied over the enzyme layer that limits the number of glucose molecules from a patient'"'"'s blood or ISF that are transferred to the enzyme layer;
a reference electrode; and
wherein the interference membrane is constructed to be (1) non-electron conducting, (2) ion permeable, and (3) permselective for molecular weight.
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Accused Products
Abstract
Briefly, a sensor for a continuous biological monitor is provided that has a working electrode with a new interfere layer that is (1) non-electron conducting, (2) ion passing, and (3) permselective for molecular weight. The new interference layer is made by mixing a monomer and a mildly basic buffer, and then electropolymerizing the monomer and the buffer into a polymer. The polymer is deposited onto a working electrode for a continuous metabolic monitor, for example, using an electro depositing process in the form of cyclic voltammety (CV). The interference layer is permselectable for molecule size by adjusting the pH of the basic buffer.
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Citations
20 Claims
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1. A subcutaneous sensor for use with a continuous metabolic monitor for a patient, comprising:
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a working electrode further comprising; a conductive substrate; an enzyme membrane comprising an enzyme selected for a target metabolic function; an interference membrane between the conductive substrate and the enzyme membrane, the interference membrane being conformally deposited on the substrate surface; and a glucose limiting layer applied over the enzyme layer that limits the number of glucose molecules from a patient'"'"'s blood or ISF that are transferred to the enzyme layer; a reference electrode; and wherein the interference membrane is constructed to be (1) non-electron conducting, (2) ion permeable, and (3) permselective for molecular weight. - View Dependent Claims (2, 3, 4, 5)
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6. A method of making a subcutaneous sensor for use with a continuous metabolic monitor, comprising:
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providing a reference electrode; providing a conductive substrate; making an interference membrane compound, further comprising; mixing a monomer and a mildly basic buffer; and electropolymerizing the monomer and the buffer into a polymer; conformally applying the polymer onto the conductive substrate to form a continuous interference membrane; applying an enzyme membrane over the interference membrane, the enzyme membrane having an enzyme selected according to the metabolic function to be monitored; applying a glucose limiting membrane over the enzyme membrane; and wherein the interference membrane (1) passes molecules to the substrate surface to generate free electrons for conducting on the conductive substrate to the continuous metabolic monitor; and
(2) restricts the passage of molecules larger than a cutoff molecular weight. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of making an interference layer for a working electrode for a continuous metabolic monitor, comprising:
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mixing a monomer and a mildly basic buffer; and electropolymerizing the monomer and the buffer into a polymer; applying the polymer to the working electrode; and curing the polymer. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification