FLUID TEST CARTRIDGE, FLUID TEST APPARATUS INCLUDING THE SAME, AND METHOD FOR CONTROLLING THE FLUID TEST APPARATUS

• US 20190310247A1
• Filed: 09/27/2018
• Published: 10/10/2019
• Est. Priority Date: 04/06/2018
• Status: Active Application

• Current Assignee: Precision Biosensor Inc.
• Original Assignee: Samsung Electronics Co. Ltd.
• Inventors: TAK, Yu Kyung, PARK, Sung Ha, TAGUCHI, Takayuki
• Application Number:
  US16/144,533
• Publication Number:
  US 20190310247A1
• Time in Patent Office: Days
• CPC Class Codes: G01N 2021/0325 Cells for testing reactions, e.g. containing reagents
• CPC Class Codes: G01N 2021/7786 Fluorescence
• CPC Class Codes: G01N 2021/825 Agglutination
• CPC Class Codes: G01N 21/77 by observing the effect on a chemical indicator
• CPC Class Codes: G01N 21/78 producing a change of colour
• CPC Class Codes: G01N 33/5306 Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
• CPC Class Codes: G01N 33/54346 Nanoparticles
• CPC Class Codes: G01N 33/54386 Analytical elements
• CPC Class Codes: G01N 33/552 Glass or silica

Abstract

A fluid test cartridge, a fluid test apparatus, and a method for controlling the same. The fluid test apparatus includes a housing, and a fluid test cartridge that is accommodated in the housing. The fluid test cartridge includes at least one chamber in which a fluid sample to be tested and a drying reagent can be accommodated. The fluid test apparatus includes a light emitter configured to emit light to the at least one chamber, a light sensor, and a processor configured to detect a concentration of a first material in the fluid sample. The drying reagent includes a non-metallic particle bound to a second material that specifically binds to the first material. Tests can thus be carried out over a wider range of wavelengths, and testing errors can be reduced.

Claims

1. A fluid test apparatus comprising:

a housing;

a fluid test cartridge that is accommodated in the housing, the fluid test cartridge including at least one chamber configured to accommodate a fluid sample and a drying reagent;

a light emitter configured to emit light towards the at least one chamber;

a light sensor configured receive the light incident on the at least one chamber and to detect optical property of a first material included in the fluid sample based on the received light; and

a processor configured to determine a concentration of the first material based on the optical property detected by the light sensor,

wherein the drying reagent includes a non-metallic particle bound to a second material that specifically binds to the first material.

2. The fluid test apparatus of claim 1, wherein the non-metallic particle comprises at least one of a monomer or a complex.

3. The fluid test apparatus of claim 1, wherein the non-metallic particle is a nano-sized particle, and the nano-sized particle is at least one element selected from the group consisting of carbon nanoparticles, ceramic nanoparticles, and polymeric nanoparticles.

4. The fluid test apparatus of claim 3, wherein the ceramic nanoparticle is at least one element selected from the group consisting of glass and nano-silica.

5. The fluid test apparatus of claim 3, wherein the polymeric nanoparticle is at least one element selected from the group consisting of polymethyl methacrylate, polystyrene, cellulose, latex, hydrogel, and agarose.

6. The fluid test apparatus of claim 1, wherein the first material is at least one element selected from the group consisting of antigens, DNA, RNA, oligosaccharides, peptides, small molecules, and proteins.

7. The fluid test apparatus of claim 1, wherein the second material is at least one element selected from the group consisting of antibodies, oligonucleotides, and proteins.

8. The fluid test apparatus of claim 1, wherein the drying reagent further comprises an activator for facilitating a reaction between the fluid sample and the drying reagent.

9. The fluid test apparatus of claim 1, wherein the at least one chamber comprises a first chamber which accommodates a first drying reagent, and a second chamber which accommodates a second drying reagent.

10. The fluid test apparatus of claim 1, wherein the drying reagent blocks an entire wavelength range of visible light.

11. The fluid test apparatus of claim 1, wherein the processor is further configured to determine concentration values of the first material over a plurality of wavelength bands of light received by the light sensor.

12. A fluid test cartridge comprising:

an inlet through which a fluid sample is introduced;

a tester configured to receive the fluid sample from the inlet and to test the fluid sample, wherein the tester comprises at least one chamber that accommodates the fluid sample introduced through the inlet and a drying reagent, the drying reagent including a non-metallic particle bound to a second material that specifically binds to a first material included in the fluid sample.

13. The fluid test cartridge of claim 12, wherein the non-metallic particle comprises at least one of a monomer or a complex.

14. The fluid test cartridge of claim 12, wherein the non-metallic particle is a nano-sized particle, and is at least one element selected from the group consisting of carbon nanoparticles, ceramic nanoparticles, polymeric nanoparticles.

15. The fluid test cartridge of claim 14, wherein the ceramic nanoparticle is at least one element selected from the group consisting of glass and nano-silica.

16. The fluid test cartridge of claim 14, wherein the polymeric nanoparticle is at least one element selected from the group consisting of polymethyl methacrylate, polystyrene, cellulose, latex, hydrogel, and agarose.

17. The fluid test cartridge of claim 12, wherein the first material in the fluid sample is at least one element selected from the group consisting of antigens, DNA, RNA, oligosaccharides, peptides, small molecules, and proteins.

18. The fluid test cartridge of claim 12, wherein the second material is at least one element selected from the group consisting of antibodies, oligonucleotides, and proteins.

19. A method for controlling a fluid test apparatus including a fluid test cartridge including at least one chamber configured to accommodate a fluid sample to be tested, and a detector configured to detect a reaction in the fluid test cartridge, the method comprising:

mounting the fluid test cartridge in a housing of the fluid test apparatus;

reacting the fluid sample accommodated in the at least one chamber with a drying reagent accommodated in the at least one chamber, the drying reagent including a non-metallic particle bound to a second material that specifically binds to a first material in the fluid sample; and

analyzing a reaction in the fluid test cartridge by measuring an optical property of the first material with the detector.

20. The method for controlling the fluid test apparatus of claim 19, wherein the at least one chamber includes a first chamber accommodating a first drying reagent, and a second chamber accommodating a second drying reagent, and

the analyzing comprises measuring a first optical property in the first chamber with the detector, and measuring a second optical property in the second chamber with the detector.